LABORATORY AND CLINICAL STUDIES ON INTRAVENOUS FOSFOMYCIN IN THE FIELD OF INTERNAL MEDICINE

Fosfomycin (FOM) was intravenously administered to 11 cases with various infections in the field of internal medicine, and the following results were obtained. 1) FOM showed relatively strong antibacterial activity against Pseudomonas aeruginosa. 2) Out of 11 cases, an excellent or a good result was...

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Published inCHEMOTHERAPY Vol. 23; no. 11; pp. 3359 - 3364
Main Authors ITO, AKIRA, YAMAZAKI, RYUICHIRO, KURIHARA, MAKIO, ODAGIRI, SHIGEKI
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1975
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Summary:Fosfomycin (FOM) was intravenously administered to 11 cases with various infections in the field of internal medicine, and the following results were obtained. 1) FOM showed relatively strong antibacterial activity against Pseudomonas aeruginosa. 2) Out of 11 cases, an excellent or a good result was obtained in 7, the efficacy rate being 63.6%. 3) With regards to side effects, 1 had positive urine protein, and 2 had increases of GOT and GPT. Apnea was seen in 1 case. This tendency seemd to be due to the excessive speed of i. v. injection. 4) FOM seems to be a unique antibiotic by virtue of having strong antibacterial activity against Pseudomonas spp.; though the care for administration method, especially, the speed of i. v. injection and the reconstituting amount will be necessary.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.23.3359