Studies on Defence Effects of Recombinant Human Granulocyte Colony-Stimulating Factor (G-CSF) to Infections I. Induction of Neutrophil Polarization by G-CSF

It is well known that recombinant human granulocyte increases dramatically the number of granulocytes in peripheral blood. It is interesting to see if G-C SF enhances the functions of neutrophil since the neutrophil is one of the most important factors of host defence mechanism against infections. I...

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Published inKansenshogaku Zasshi Vol. 64; no. 4; pp. 425 - 429
Main Authors HIROTA, Masaki, KADOTA, Jun-ichi, SENJU, Reiko, FUKUSHIMA, Kiyoyasu, HIRATANI, Kazuhito, DOTSU, Yasumasa, KOMORI, Kiyotaka, KOHNO, Shigeru, HARA, Kohei, TOMONO, Kazunori, YAMAGUCHI, Keizou
Format Journal Article
LanguageJapanese
Published Japan The Japanese Association for Infectious Diseases 01.04.1990
Subjects
Cells, Cultured
Chemotaxis, Leukocyte - physiology
Colony-Stimulating Factors - physiology
Granulocyte Colony-Stimulating Factor
Humans
Immunity, Innate
neutrophil
Neutrophils - physiology
polarization
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Summary:It is well known that recombinant human granulocyte increases dramatically the number of granulocytes in peripheral blood. It is interesting to see if G-C SF enhances the functions of neutrophil since the neutrophil is one of the most important factors of host defence mechanism against infections. In this study, we have demonstrated that G-CSF induced the polarization of neutrophil while it could not be chemoattractant for the cell. Polarization is considered to be the initial reaction of chemotaxis. Therefore, G-CSF might enhance the defence effect of the neurophil to infections in this point.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0387-5911
1884-569X
DOI:10.11150/kansenshogakuzasshi1970.64.425