LABORATORY AND SURGICAL STUDIES OF, CLINDAMYCIN

• Published in: CHEMOTHERAPY Vol. 17; no. 5; pp. 878 - 880
• Main Authors: ISHII, RYOJI, ISHIBIKI, KISAYA, YAMAGUCHI, KAZUKUNI, OHSUGA, SIRO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1969
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.17.878

Laboratory and surgical studies of clindam ycin, a new derivative of lincomycin, were conducted with the following results: 1. In an evalua tion of the in vitro antibacterial activity of clindamycin, the minimal inhibitory concentrations determined against 51 strains of Staphylococcus aureus isolated from the lesion of various surgical infections were 0. 9 mcg/ml or below in 47 strains, 3. 12 mcg/m1 in 1 and 100 mcg/ml or above in 3. 2. Wit h a single oral dose of 150 mg, the blood level reached the peak of 1. 19 mcg/m1 at 2 hour. In the case of a 300 mg also orally dosed, the peak level was 3. 57 mcg/ml at 1 hour. 3. Clindamycin was administered to 35 patients with surgical infections such a s furuncle, cellulitis, felon, carbuncle, acute suppurative mastitis, abscess, osteomyelitis, erysipelas, etc., and an excellent or good clinical response was observed in 29 (82. 9%) of them. 4. No side effects were noted except abdominal pain in I patient and slight digestive disturbance in 2 patients.