ANTIMICROBIAL ACTIVITY OF BIS(2-PYRIDYL-N-OXIDE)-DISULFIDE

• Published in: CHEMOTHERAPY Vol. 15; no. 3; pp. 224 - 227
• Main Authors: KAWABE, KIYOSHI, KANAZAWA, TAMOTSU, TAKIMOTO, GIICHI, IKEDA, TOMOHISA, SATO, MASARU, KANO, SEIZABURO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1967
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.15.224

1) In vitro antimicrobial activities of bis(2-pyridyl-N-oxide)-disulfide (PODS) on gram positive and negative bacteria, various fungi, Mycobacterium tuberculosis, and Trichomonas vaginalis, were tested. As the results, the growth of these microorganisms were inhibited by low concentrations ( 0. 2 ? 6, 25 mcg/ml) of PODS. 2) Phenol coef ficients of PODS were 34 on Staphylococcus aureus 209 P and 3. 4 on Salmonella typhosa H 9 01W. 3) Acute toxicities (LD50) of PODS in mice showed 382 mg/kg (p. o. ) and 49 mg/kg(i. p. ). 4) In the case of subcutaneous administration (20 m g/kg) of PODS in mice infected with Staphylococcus and Streptococcus, the therapeutic effects were not shown. As the reason, it is speculated that PODS is easily inactivated by enzyme in animal organs. But dermatomycosis of guinea pigs was cured d y applying of 1% PODS solution once a day for 9 days.