血しょう交換装置を利用した血中α‐フェトプロテイン除去による肝細胞がん治療へのアプローチ

• Published in: Jinko Zoki Vol. 11; no. 1; pp. 70 - 73
• Main Authors: 松本 雄幸, 溝上 雅史, 中村 憲一郎, 奥田 宣男, 御供 泰治, 山本 正彦, 加納 英行, 稲垣 豊, 天野 泉
• Format: Journal Article
• Language: Japanese
• Published: 一般社団法人 日本人工臓器学会 1982; JAPANESE SOCIETY FOR ARTIFICIAL ORGANS
• Subjects: AFP; anti-AFP-antibodies; hepatoma; plasma exchange
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.11.70

The effect of the Plasma Exchange in eliminating blood AFP was evaluated in the patients with hepatoma.The blood AFP was decreased by 68%-90% (mean ± SD=75.1 ± 10.3, n=6 in 3 cases) with the membrane plasma separater and by 35%-72% (mean ± SD) =58 ± 12.3, n=3 in 1 case) with the centrifuge plasma separater.In all cases, the symptoms were improved by the plasma exchange. Mild side effects (eruptions and fever) appeared in 22% of the trials. Tsukada et al. reported that anti-AFP-antibodies had cytotoxity to hepatoma cells. We expect that plasma exchange may prevent the formation of Ag-Ab complexes in the blood and may potentiate the effect of anti-AFP-antibodies against hepatoma cells.