GENTAMICIN RESISTANT BACILLI Epidemiologic Aspects in Six Hospitals

• Published in: CHEMOTHERAPY Vol. 24; no. 7; pp. 1506 - 1510
• Main Authors: KOBAYASI, AKIO, IWAMA, HIROMI, KUBO, SETSUKO, SHIMADA, KAORU, INAMATSU, TAKASHI, KONNO, MASATOSHI, UBUKATA, KIMIKO, TOMIOKA, SUSUMU, KOBAYASHI, YOSHIO, UCHIDA, HIROSHI, SAITO, ATSUSHI, UEDA, YASUSHI, SHIMIZU, KIHACHIRO, OKUZUMI, KATSUKO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1976
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.24.1506

Strains of gram-negative bacilli resistant to gentamicin were collected among the all isolates in five university hospitals and an affiliated hospital of Tokyo area during the 3-month period from January through March 1975. The resistant strains were detected in remarkably different isolation-rate, ranging from 0.4 to 11. 1 percent, according to each hospital from the gram-negative bacilli. As for the species of the strains, Providencia, Proteus sp. and Pseudomonas aeruginosa had higher iso-lation-rate than that of Escherichia coli and Klebsiella. The strains were isolated more frequently from urine and pus in the specimens. It was not observed a definite relationship between the amount of gentamicin used in a hospital during a year period and the number of the resistant strains isolated. The fact that many resistant strains were isolated from the patients who had not been administered gentamicin suggests the frequent opportunity of cross-infections in the hospital. The topical therapy of the antibiotics seemed to promote the emergence of the resistant strains.