LABORATORY AND CLINICAL STUDIES OF TICARCILLIN

• Published in: CHEMOTHERAPY Vol. 25; no. 9; pp. 2809 - 2820
• Main Authors: SHIMAZU, RYOICHI, KATO, NAOKI, KAWADA, YUKIMICHI, NISHIURA, TSUNEO, MIYAMURA, RYUZO, TAHARA, TATSUO, NISHIMURA, YOJI, SAITO, ISAO, SHIMIZU, YASUO, ISOGAI, KAZUTOSHI
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1977
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.25.9_2809

Laboratory and clinical investigations were performed on a new synthetic penicillin, ticarcillin (TIPC), and the following conclusions were obtained. 1. Antibacterial activity of TIPC against 40 strains of Ps. aeruginosa derived from urinary tract, was about 2 times stronger than that of SBPC. Antibacterial activity of CEZ against ABPC resistant E. coil, was superior to that of TIPC, and yet 25% of the strains showed MIC of TIPC ≤ 50μg/ml, while MIC of CEZ≥ 100 μg/ ml. 2. Growth inhibitory effect of TIPC against Ps. aeruginosa, was found in concentration of 1-2MIC, and this remained perfectly for 24 hours. 3. Clinical investigation was made on 40 cases of chronic urinary tract infection. As the results, overall efficacy rate was 38.9% in 18 cases judged on 3rd day, 51.5% in 33 cases judged on 5th day, and 53.8% in 39 cases judged on 7th day. Overall efficacy rate was 50.0% in 22 cases administered a daily dose of 2 g, and 58. 8% in 17 cases administered 3 g. As to the cases under catheterization, efficacy was better at a daily dose of 3 g. 4. As for the side effect, eruption was observed only in 1 case out of all 43 cases treated. As to the laboratory test values, GOT and GPT were elevated slightly only in 1 case.