A DOUBLE BLIND CLINICAL STUDY OF CARFECILLIN AND AMPICILLIN IN ACUTE SIMPLE CYSTITIS

• Published in: CHEMOTHERAPY Vol. 23; no. 7; pp. 2487 - 2496
• Main Authors: KAWADA, YUKIMICHI, SHIOMI, YOKO, ITO, FUMIO, NISHIURA, TSUNEO, KUMAMOTO, YOSHIAKI, MIYAMURA, RYUZO, TAHARA, TATSUO, TOFUKUJI, HIDEYUKI, NISHIMURA, YOJI, IKI, YOSHIO, SAITO, TOYOICHI, SAITO, ISAO, NAGAKUBO, ICHIRO, UNNO, RYOJI, OHKOSHI, MASAAKI, NAIDE, YORIO
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Chemotherapy 1975
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.23.2487

Carfecillin, carbenicillin phenyl ester, has been compared with ampicillin (ABPC) on the clinical effect and side effect by means of a double blind test on the cases of acute simple cystitis. Carfecillin (one tablet containing 250 mg) and ABPC (one tablet containing 250 mg) were administered at a dose of 2 tablets 4 times a day for 3 days respectively. The transition of subjective and objective symptoms were studied on 3 rd or 4 th day after the initiation of administration, and the recurrence was examined on the 7 th day after the discontinuance of administration. The criteria of judgement of clinical effect are shown in Fig. 1. One hundred and eighty-one cases (carfecillin 88 cases, ABPC 93 cases) were discussed about clinical effects. The constitutions of cases and the clinical results of two drugs were compared statistically by means of X2 test, MANN-WHITNEY U test, FISHER's exact probability test and Sign test. No significant difference was observed between two drug groups on the constitution of cases, i. e., age, body weight, days after onset of symptoms, grade of pyuria, frequency of appearance of each symptoms, infecting organisms and their MIC of carbenicillin or ABPC. As for the clinical results, the excellent effective cases were 40. 9% with carfecillin and 46. 2% with ABPC, and the good effective cases were 52. 3% with carfecillin and 50.6% with ABPC. The statistical examination was tried between two drugs, and no significant difference was observed. Concerning the effect on symptom, pyuria and bacteriuria, the statistical examinations were also tried between two drugs, and no significant differences were observed in the effect on symptom and bacteriuria. But concerning the effect on pyuria, “persisted” rate was 12.5% with carfecillin and 3.2% with ABPC, and the difference between two drugs was statistically significant at the level of 5%. The patients discussed about recurrence were 114 cases (carfecillin 52 cases, ABPC 62 cases). Ratio of recurrence was 13.5% in carfecillin group and 19.4% in ABPC. No significant difference was observed between two drug groups. The side effects were followed in 213 cases (carfecillin 106 cases, ABPC 107 cases) and the appearance ratio was 2.8% (3 cases) in carfecillin group and 5.6% (6 cases) in ABPC group, showing no significant difference between two drugs. The kind of the side effects was gastro-intestinal disorder in carfecillin group, but was mainly eruption in ABPC group. In short, a quite similar result was obtained both with carfecillin and ABPC on the clinical effect, recurrence and side effect in the treatment of acute simple cystitis.