A BASIC STUDY ON PIPEMIDIC ACID AND ITS APPLICATION TO PULMONARY INFECTIOUS DISEASES

Pipemidic acid (PPA), a derivative of piromidic acid (Panacid®), was studied basically and clinically, and the following results were obtained. The antibacterial activity of PPA was lower against Pseudomonas aeruginosa and Klebsiella than E. coli and Proteus. The MIC values of the latter two organis...

Full description

Saved in:
Bibliographic Details
Published inCHEMOTHERAPY Vol. 23; no. 9; pp. 2870 - 2873
Main Authors TOKUNAGA, KATSUMASA, SHIMA, KIYOSHI, FUKUDA, YASUTSUGU, HAMADA, KAZUHIRO, TOKUOMI, HARUHIKO
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Society of Chemotherapy 1975
Online AccessGet full text

Cover

More Information
Summary:Pipemidic acid (PPA), a derivative of piromidic acid (Panacid®), was studied basically and clinically, and the following results were obtained. The antibacterial activity of PPA was lower against Pseudomonas aeruginosa and Klebsiella than E. coli and Proteus. The MIC values of the latter two organisms were usually below 6.25 μg/ml. Concentrations in serum after single oral administration of 500 mg PPA attained a peak ranging 2.5 to 4.1 μg/ml in 2 to 4 hours. PPA was clinically used in 18 cases of respiratory infections and the efficacy rate was 47.1 %.As for side effects, five cases complained of gastro-intestinal disturbance, though the symptoms ceased after stopping administration.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.23.2870