Protective Activity of S-PT84, a Heat-killed Preparation of Lactobacillus pentosus, against Oral and Gastric Candidiasis in an Experimental Murine Model

• Published in: Medical Mycology Journal Vol. 55; no. 3; pp. J123 - J129
• Main Authors: Hayama, Kazumi, Ishijima, Sanae, Ono, Yoshiko, Izumo, Takayuki, Ida, Masayuki, Shibata, Hiroshi, Abe, Shigeru
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society for Medical Mycology 2014
• Subjects: anti-Candida treatment; Candida albicans; gastrointestinal tract; Lactobacillus pentosus
• ISSN: 2185-6486; 2186-165X
• DOI: 10.3314/mmj.55.J123

The effect of S-PT84, a heat-killed preparation of Lactobacillus pentosus on growth of Candida albicans was examined in vitro and in vivo. The mycelial growth was effectively inhibited by S-PT84 and seemed to bind to the hyphae. We assessed the potential of S-PT84 for treatment of oral and gastric candidiasis using a murine model. When 2 mg of S-PT84 was administered three times into the oral cavity of orally Candida infected mice, the score of lesions on the tongue was improved on day 2. When 50μl and 200μl of S-PT84 (10 mg/ml) were administered three times into the oral cavity (0.5 mg × 3) and the stomach (2 mg × 3) of the same mouse model, the number of viable Candida cells in the stomach was reduced significantly on day 2. These findings suggest the possibility that S-PT84 has potential as a food ingredient supporting anti-Candida treatment, especially for Candida infection in the gastrointestinal tract.