A case of refractory adult-onset Still's disease with high serum interleukin-18 levels treated with monitoring of serum levels of cyclosporine

We report the case of a 31-year-old woman who developed adult-onset Still's disease (AOSD) with a high level of serum interleukin (IL)-18. Although treated with high dose steroids, she suffered repeated remissions and her condition deteriorated. After we administered oral cyclosporine A (CsA),...

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Bibliographic Details
Published inFukuoka igaku zasshi = Hukuoka acta medica Vol. 103; no. 1; p. 24
Main Authors Horai, Yoshiro, Koyama, Atsuko, Miyamura, Tomoya, Hirata, Akie, Nakamura, Masataka, Ando, Hitoshi, Takahama, Soichiro, Minami, Rumi, Yamamoto, Masahiro, Suematsu, Eiichi
Format Journal Article
LanguageEnglish
Published Japan 01.01.2012
Subjects
Administration, Oral
Adult
Cyclosporine - administration & dosage
Cyclosporine - blood
Environmental Monitoring
Female
Humans
Interleukin-18 - blood
Still's Disease, Adult-Onset - blood
Still's Disease, Adult-Onset - drug therapy
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Summary:We report the case of a 31-year-old woman who developed adult-onset Still's disease (AOSD) with a high level of serum interleukin (IL)-18. Although treated with high dose steroids, she suffered repeated remissions and her condition deteriorated. After we administered oral cyclosporine A (CsA), 200 mg/d, monitoring C2 and trough levels, her symptoms improved significantly. We decreased the dose of methylprednisolone slowly without noting a relapse. The use of CsA accompanied by C2 and trough level monitoring should be considered for refractory AOSD patients with high levels of serum IL-18.
ISSN:0016-254X