All-trans retinoic acidにより寛解導入に成功した急性前骨髄性白血病小児再発例
All-trans retinoic acid (ATRA) により寛解導入に成功した5歳男児急性前骨髄性白血病再発例を報告した・再発後, 化学療法に抵抗性のため両親の承諾を得たうえでAra-C大量療法後ATRA60mg/m2/dayの経口投与を開始した.投与64日で完全寛解を得た.末梢血像, 骨髄像, および末梢血フローサイトメトリーにてATRAによる白血病細胞の分化過程が観察できた.本症例は染色体分析にてt (15;17) が認められた.またDNA分析ではRAレセプターα (RARα) の再構成が認められた.ATRAは副作用も少なく, 小児の急性前骨髄性白血病には非常に有効と考えた....
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| Published in | 日本小児血液学会雑誌 Vol. 6; no. 5; pp. 493 - 498 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
特定非営利活動法人 日本小児血液・がん学会
1992
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| Online Access | Get full text |
| ISSN | 0913-8706 1884-4723 |
| DOI | 10.11412/jjph1987.6.493 |
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| Abstract | All-trans retinoic acid (ATRA) により寛解導入に成功した5歳男児急性前骨髄性白血病再発例を報告した・再発後, 化学療法に抵抗性のため両親の承諾を得たうえでAra-C大量療法後ATRA60mg/m2/dayの経口投与を開始した.投与64日で完全寛解を得た.末梢血像, 骨髄像, および末梢血フローサイトメトリーにてATRAによる白血病細胞の分化過程が観察できた.本症例は染色体分析にてt (15;17) が認められた.またDNA分析ではRAレセプターα (RARα) の再構成が認められた.ATRAは副作用も少なく, 小児の急性前骨髄性白血病には非常に有効と考えた. |
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| AbstractList | All-trans retinoic acid (ATRA) により寛解導入に成功した5歳男児急性前骨髄性白血病再発例を報告した・再発後, 化学療法に抵抗性のため両親の承諾を得たうえでAra-C大量療法後ATRA60mg/m2/dayの経口投与を開始した.投与64日で完全寛解を得た.末梢血像, 骨髄像, および末梢血フローサイトメトリーにてATRAによる白血病細胞の分化過程が観察できた.本症例は染色体分析にてt (15;17) が認められた.またDNA分析ではRAレセプターα (RARα) の再構成が認められた.ATRAは副作用も少なく, 小児の急性前骨髄性白血病には非常に有効と考えた. |
| Author | 太田, 茂 多賀, 崇 島田, 司巳 丸尾, 良浩 杉浦, 康夫 |
| Author_xml | – sequence: 1 fullname: 島田, 司巳 organization: 滋賀医科大学小児科 – sequence: 1 fullname: 多賀, 崇 organization: 滋賀医科大学小児科 – sequence: 1 fullname: 杉浦, 康夫 organization: 滋賀医科大学小児科 – sequence: 1 fullname: 太田, 茂 organization: 滋賀医科大学小児科 – sequence: 1 fullname: 丸尾, 良浩 organization: 滋賀医科大学小児科 |
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| References | 4) Castaigne S, Chomienne C, Daniel MT, et al : Alltrans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 76 : 1704-1709, 1990 6) Chomienne C, Lanotte M, Degos L, et al : The t (15; 17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 347 : 558-560, 1990 1) Huang ME, Ye HC, Chen SR, et al : Use of alltrans retinoic acid in the treatment of acute promylocytic leukemia. Blood 72 : 567-572, 1988 9) Breitman TR, Selonick SE, Collins S J : Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc. Natl Acad Sci USA 77 : 2936-2940, 1980 5) Borrow J, Goddard AD, Sheer D, et al : Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249 : 1577-1580, 1990 3) Castaigne S, Chomienne C, Daniel MT, et al : Retinoic acids in the treatment of acute promyelocytic leukemia. Nouv Rev Fr Hematol 32 : 36-38, 1990 10) Flynn P, Miller W, Weisdorf D, et al : Retinic acid treatment of acute promyelocytic leukemia : In vitro and in vivo observations. Blood 62 : 1211-1217, 1983 15) Nakamaki T, Sakashita A, Sano S, et al : Granulocyte-colony stimulating factor and retinoic acid cooperatively induced granulocytic differentiation of acute promyelocytic leukemia cells in vitro. Jpn J Cancer Res 80 : 1077-1082, 1989 7) Longo L, Pandolifi PP, Biondi A, et al : Rearrangements and aberrant expression of the retinoic acid receptor a gene in acute promyelocytic leukemias. J Exp Med 172 : 1571-1575, 1990 11) Nilsson B : Probable in vivo induction of differentiation by retinoic acid of promyelocytes in acute promyelocytic leukemia. Br J Hematol 57 : 365-371, 1984 16) Chen ZX, Xue YQ, Zhang R, et al : A clinical and experimental study on all-trans retinoic acidtreated acute promyelocytic leukemia patients. Blood 78 : 1413-1419, 1991 12) Daenen S, Vellenga E, van Dobbenbugh, et al : Retinoic acid as antileukemic therapy in a patient with acute promyelocytic leukemia and Aspergillus pneumonia. Blood 67 : 559-561, 1986 8) Bennett JM, Catovsky D, Daniel MT, et al : Proposals for the classification of the acute leukemia. Br J Hematol 33 : 451-458, 1976 17) Cornic M, Delva L, Balitrand N, et al : Characterization of cytoplasmic retinoic acid binding protein (CRABP) during therapy of RA in promyelocytic acute leukemia. Proc Am Assoc Cancer Res 32 : 23, 1991 2) Wang ZY, Sun GL, Lu JX, et al : Treatment of acute promyelocytic leukemia with all-trans retinoic acid in China. Nouv Rev Fr Hematol 32 : 34-36, 1990 14) Chomienne C, Ballerini P, Baltrand N, et al : Alltrans retinoic acid in acute promyelocytic leukemias. II. In vitro studies : Structure-function relationship. Blood 76 : 1710-1717, 1990 13) Fontana JA, Roger JS, Durhaim JP : The role of 13-cis retinoic acid in the remission induction of a patient with acute promyelocytic leukemia.Cancer 57 : 209-217, 1986 |
| References_xml | – reference: 17) Cornic M, Delva L, Balitrand N, et al : Characterization of cytoplasmic retinoic acid binding protein (CRABP) during therapy of RA in promyelocytic acute leukemia. Proc Am Assoc Cancer Res 32 : 23, 1991 – reference: 7) Longo L, Pandolifi PP, Biondi A, et al : Rearrangements and aberrant expression of the retinoic acid receptor a gene in acute promyelocytic leukemias. J Exp Med 172 : 1571-1575, 1990 – reference: 8) Bennett JM, Catovsky D, Daniel MT, et al : Proposals for the classification of the acute leukemia. Br J Hematol 33 : 451-458, 1976 – reference: 4) Castaigne S, Chomienne C, Daniel MT, et al : Alltrans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results. Blood 76 : 1704-1709, 1990 – reference: 1) Huang ME, Ye HC, Chen SR, et al : Use of alltrans retinoic acid in the treatment of acute promylocytic leukemia. Blood 72 : 567-572, 1988 – reference: 2) Wang ZY, Sun GL, Lu JX, et al : Treatment of acute promyelocytic leukemia with all-trans retinoic acid in China. Nouv Rev Fr Hematol 32 : 34-36, 1990 – reference: 10) Flynn P, Miller W, Weisdorf D, et al : Retinic acid treatment of acute promyelocytic leukemia : In vitro and in vivo observations. Blood 62 : 1211-1217, 1983 – reference: 14) Chomienne C, Ballerini P, Baltrand N, et al : Alltrans retinoic acid in acute promyelocytic leukemias. II. In vitro studies : Structure-function relationship. Blood 76 : 1710-1717, 1990 – reference: 12) Daenen S, Vellenga E, van Dobbenbugh, et al : Retinoic acid as antileukemic therapy in a patient with acute promyelocytic leukemia and Aspergillus pneumonia. Blood 67 : 559-561, 1986 – reference: 5) Borrow J, Goddard AD, Sheer D, et al : Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science 249 : 1577-1580, 1990 – reference: 3) Castaigne S, Chomienne C, Daniel MT, et al : Retinoic acids in the treatment of acute promyelocytic leukemia. Nouv Rev Fr Hematol 32 : 36-38, 1990 – reference: 6) Chomienne C, Lanotte M, Degos L, et al : The t (15; 17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor α gene to a novel transcribed locus. Nature 347 : 558-560, 1990 – reference: 15) Nakamaki T, Sakashita A, Sano S, et al : Granulocyte-colony stimulating factor and retinoic acid cooperatively induced granulocytic differentiation of acute promyelocytic leukemia cells in vitro. Jpn J Cancer Res 80 : 1077-1082, 1989 – reference: 9) Breitman TR, Selonick SE, Collins S J : Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid. Proc. Natl Acad Sci USA 77 : 2936-2940, 1980 – reference: 16) Chen ZX, Xue YQ, Zhang R, et al : A clinical and experimental study on all-trans retinoic acidtreated acute promyelocytic leukemia patients. Blood 78 : 1413-1419, 1991 – reference: 11) Nilsson B : Probable in vivo induction of differentiation by retinoic acid of promyelocytes in acute promyelocytic leukemia. Br J Hematol 57 : 365-371, 1984 – reference: 13) Fontana JA, Roger JS, Durhaim JP : The role of 13-cis retinoic acid in the remission induction of a patient with acute promyelocytic leukemia.Cancer 57 : 209-217, 1986 |
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| Title | All-trans retinoic acidにより寛解導入に成功した急性前骨髄性白血病小児再発例 |
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