サイトカインの基礎と臨床IL-2の臨床応用
IL-2の抗腫瘍効果をみるため, 4名の担癌患者にrecombinant (r) IL-2を3.3～10×105 U/日, 5～20日間点滴静注したが効果は認められなかった.ついで8名の従来の治療が無効な担癌患者に対しrIL-2のadoptive immunotherapyを行ったところ,多発性骨髄腫2例において,末梢血リンパ球数の増加, Leu 7, OKM 1, OKT 10陽性細胞の増加, NK, LAK活性の上昇がみられ,血中M蛋白濃度の25～50%の減少がみられた.皮膚悪性リンパ腫の患者では皮膚病変の改善が,赤白血病では白血病に至るstageを遅延させている所見がみられた....
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| Published in | 日本臨床免疫学会会誌 Vol. 9; no. 5; pp. 345 - 349 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
日本臨床免疫学会
1986
|
| Online Access | Get full text |
| ISSN | 0911-4300 1349-7413 |
| DOI | 10.2177/jsci.9.345 |
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| Abstract | IL-2の抗腫瘍効果をみるため, 4名の担癌患者にrecombinant (r) IL-2を3.3～10×105 U/日, 5～20日間点滴静注したが効果は認められなかった.ついで8名の従来の治療が無効な担癌患者に対しrIL-2のadoptive immunotherapyを行ったところ,多発性骨髄腫2例において,末梢血リンパ球数の増加, Leu 7, OKM 1, OKT 10陽性細胞の増加, NK, LAK活性の上昇がみられ,血中M蛋白濃度の25～50%の減少がみられた.皮膚悪性リンパ腫の患者では皮膚病変の改善が,赤白血病では白血病に至るstageを遅延させている所見がみられた. |
|---|---|
| AbstractList | IL-2の抗腫瘍効果をみるため, 4名の担癌患者にrecombinant (r) IL-2を3.3～10×105 U/日, 5～20日間点滴静注したが効果は認められなかった.ついで8名の従来の治療が無効な担癌患者に対しrIL-2のadoptive immunotherapyを行ったところ,多発性骨髄腫2例において,末梢血リンパ球数の増加, Leu 7, OKM 1, OKT 10陽性細胞の増加, NK, LAK活性の上昇がみられ,血中M蛋白濃度の25～50%の減少がみられた.皮膚悪性リンパ腫の患者では皮膚病変の改善が,赤白血病では白血病に至るstageを遅延させている所見がみられた. |
| Author | 戸川, 敦 |
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| Copyright | 日本臨床免疫学会 |
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| DOI | 10.2177/jsci.9.345 |
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| EndPage | 349 |
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| References | 5) Ettinghausen, S. E., Rosenberg, S. A.: Immunotherapy of murine sarcomas using lymphokine activated killer cells: optimization of the schedule and route of administration of recombinant interleukin-2. Cancer Res., 46: 2784-2792, 1986. 2) Lotze, M. T., Robb, R. J., Sharrow, S. O., Frana, L. W., Rosenberg, S. A.: Systemic administration of interleukin-2 in humans. J. Biol. Response Mod., 3: 475-482, 1984. 3) Lotze, M. T., Matory, Y. L., Ettinghausen, S. E., Rayner, A. A., Sharrow, S. O., Seipp, A. Y., Custer, M. C., Rosenberg, S. A.: in vivo administration of purified human interleukin 2 II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL-2. J. Immunol., 135: 2865-2875, 1985. 1) Rosenberg, S. A., Lotze, M. T., Muul, L. M., Leitman, S. L., Chang, A. E., Ettinghausen, S. E., Matory, Y. L., Skibber, J. M., Shiloni, E., Vetto, J. T., Seipp, C. A., Simpson, C., Reichert, C. M.: Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. New Engl. J. Med., 313: 1485-1492, 1985. 4) Rosenberg, S. A., Mule, J. J., Spiess, P. J., Reichert, C. M., Schwarz, S. L.: Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin-2. J. Exp. Med., 61: 1169-1188, 1985. |
| References_xml | – reference: 2) Lotze, M. T., Robb, R. J., Sharrow, S. O., Frana, L. W., Rosenberg, S. A.: Systemic administration of interleukin-2 in humans. J. Biol. Response Mod., 3: 475-482, 1984. – reference: 1) Rosenberg, S. A., Lotze, M. T., Muul, L. M., Leitman, S. L., Chang, A. E., Ettinghausen, S. E., Matory, Y. L., Skibber, J. M., Shiloni, E., Vetto, J. T., Seipp, C. A., Simpson, C., Reichert, C. M.: Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. New Engl. J. Med., 313: 1485-1492, 1985. – reference: 4) Rosenberg, S. A., Mule, J. J., Spiess, P. J., Reichert, C. M., Schwarz, S. L.: Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin-2. J. Exp. Med., 61: 1169-1188, 1985. – reference: 3) Lotze, M. T., Matory, Y. L., Ettinghausen, S. E., Rayner, A. A., Sharrow, S. O., Seipp, A. Y., Custer, M. C., Rosenberg, S. A.: in vivo administration of purified human interleukin 2 II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL-2. J. Immunol., 135: 2865-2875, 1985. – reference: 5) Ettinghausen, S. E., Rosenberg, S. A.: Immunotherapy of murine sarcomas using lymphokine activated killer cells: optimization of the schedule and route of administration of recombinant interleukin-2. Cancer Res., 46: 2784-2792, 1986. |
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| Snippet | IL-2の抗腫瘍効果をみるため, 4名の担癌患者にrecombinant (r) IL-2を3.3～10×105 U/日, 5～20日間点滴静注したが効果は認められなかった.ついで8名の従来の治療が無効な担癌患者に対しrIL-2のadoptive... |
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| Title | サイトカインの基礎と臨床IL-2の臨床応用 |
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