Studies on Some Protective Actions of Sulfated Polysaccharides against the Development of Arteriosclerosis III. The Preventive Action of Combined Treatment of Dextran Sulfate and Pyridoxal Phosphate against Experimental Arteriosclerosis in Rabbits

• Published in: Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics Vol. 3; no. 2; pp. 164 - 174
• Main Author: Oguri, Takeshi
• Format: Journal Article
• Language: Japanese
• Published: The Japan Geriatrics Society 1966
• ISSN: 0300-9173
• DOI: 10.3143/geriatrics.3.164

The author investigated the effect of combined treatment of dextran sulfate (DS) and pyridoxal phosphate (PAL-PO4) on the atherosclerosis in lanoline-fed rabbits. DS (intrinsic viscosity 0.030-0.045, sulfur content 3.0-6.0%) 60mg and PAL-PO4 10mg were injected intravenously twice daily during 12 weeks. The level of serum total cholesterol determined several times during 12 weeks showed no significant difference between the injected group and the control group. Nevertheless the marked prevention against atherosclerosis was observed in pathological findings after 12 weeks. In the increase percentage of non-esterified fatty acid after 15 minutes from intravenous injection of DS (1), PAL-PO4 (2) and DS+PAL-PO4 (3), difference was observed between severe and mild hyperlipemia rabbits in the above-mentioned experiment, and the similar difference was observed between the aged and young adult. Young adult and mild hyperlipemia rabbbit showed (1) > (3) > (2), while the aged and severe hyperlipemia rabbit showed (3) ≥ (1) > (2). It may be concluded from these experiments that the application of combined treatment of DS and PAL-PO4 to the aged is appropriate.