LOCAL IRRITATION STUDY OF MIPORAMICIN IN MALE RABBITS

Local irritation effect of miporamicin (MPM), a new macrolide antibiotics for animal use, on skin and ocular tissues was determined in rabbits by the primary skin irritation test and ocular irritation test, respectively. In the former test, P. I. I. and inflammatory findings increased with increasin...

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Published inJapanese journal of antibiotics Vol. 42; no. 11; pp. 2513 - 2525
Main Authors KOHIRA, TERUTOMO, NAKANISHI, DAISUKE, GOTO, IKUYO, KOBAYASHI, YOSHIRO, MATSUMOTO, KAZUHIKO, YAMAMOTO, HIROSHI
Format Journal Article
LanguageJapanese
Published Japan Japan Antibiotics Research Association 01.11.1989
Subjects
Animals
Anti-Bacterial Agents - toxicity
Conjunctiva - drug effects
Cornea - drug effects
Iris - drug effects
Irritants
Macrolides
Male
Rabbits
Skin - drug effects
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Summary:Local irritation effect of miporamicin (MPM), a new macrolide antibiotics for animal use, on skin and ocular tissues was determined in rabbits by the primary skin irritation test and ocular irritation test, respectively. In the former test, P. I. I. and inflammatory findings increased with increasing exposure time to MPM. A short-time contact with MPM caused relatively little effect on ocular tissues. Contrarily, a long-time contact with MPM caused medium or high degree of inflammatory reactions on cornea, iris and conjunctiva tissues. The increased inflammation was naturally accompanied with increases of the DRAIZE score. All these results suggest that MPM per se has local irritation effect on both skin and ocular tissues.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.42.2513