LABORATORY AND CLINICAL STUDIES OF CEFPROZIL IN PEDIATRIC FIELD

• Published in: Japanese journal of antibiotics Vol. 45; no. 11; pp. 1582 - 1591
• Main Authors: NISHIMURA, TADAFUMI, TABUKI, KAZUO, AOKI, SHIGEYUKI, TAKAGI, MICHIO
• Format: Journal Article
• Language: Japanese
• Published: Japan Japan Antibiotics Research Association 01.11.1992
• Subjects: Bacteria - drug effects; Bacteria - enzymology; Bacteria - isolation & purification; Bacterial Infections - drug therapy; Bacterial Infections - microbiology; beta-Lactamases - analysis; Cefprozil; Cephalosporins - adverse effects; Cephalosporins - pharmacokinetics; Cephalosporins - pharmacology; Cephalosporins - therapeutic use; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; Humans; Infant; Male; Microbial Sensitivity Tests

Laboratory and clinical studies were done on cefprozil (CFPZ, BMY-28100). The results are summarized as follows. CFPZ was administered through the oral route to 2 children at a single dose of 7.5mg/kg. After administration, peak serum levels of CFPZ obtained in the 2 cases were 6.71 μg/ml at 1 hour...