LABORATORY AND CLINICAL STUDIES OF CEFPROZIL IN PEDIATRIC FIELD

• Published in: Japanese journal of antibiotics Vol. 45; no. 11; pp. 1582 - 1591
• Main Authors: NISHIMURA, TADAFUMI, TABUKI, KAZUO, AOKI, SHIGEYUKI, TAKAGI, MICHIO
• Format: Journal Article
• Language: Japanese
• Published: Japan Japan Antibiotics Research Association 01.11.1992
• Subjects: Bacteria - drug effects; Bacteria - enzymology; Bacteria - isolation & purification; Bacterial Infections - drug therapy; Bacterial Infections - microbiology; beta-Lactamases - analysis; Cefprozil; Cephalosporins - adverse effects; Cephalosporins - pharmacokinetics; Cephalosporins - pharmacology; Cephalosporins - therapeutic use; Child; Child, Preschool; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; Humans; Infant; Male; Microbial Sensitivity Tests
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.45.1582

Laboratory and clinical studies were done on cefprozil (CFPZ, BMY-28100). The results are summarized as follows. CFPZ was administered through the oral route to 2 children at a single dose of 7.5mg/kg. After administration, peak serum levels of CFPZ obtained in the 2 cases were 6.71 μg/ml at 1 hour and 6.45 μg/ml at 2 hours, respectively and half-lives were 1.28 hours and 0.92 hour, respectively. The urinary excretion rates of CFPZ were 58.9% and 59.4%, respectively. Treatment with CFPZ was made in 37 cases of pediatric bacterial infections: 1 case of pharyngitis, 16 cases of tonsillitis, 16 cases of scarlet fever, 3 cases of impetigo, 1 case of UTI. Results obtained were excellent in 24 cases, good in 13 cases. No significant side effects due to the drug were observed, except 1 case of loose stool, 3 cases of eosinophilia, and 1 case each of elevated GOT and GPT.