LABORATORY AND CLINICAL STUDIES OF CEFPROZIL IN PEDIATRIC FIELD
Laboratory and clinical studies were done on cefprozil (CFPZ, BMY-28100). The results are summarized as follows. CFPZ was administered through the oral route to 2 children at a single dose of 7.5mg/kg. After administration, peak serum levels of CFPZ obtained in the 2 cases were 6.71 μg/ml at 1 hour...
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Published in | Japanese journal of antibiotics Vol. 45; no. 11; pp. 1582 - 1591 |
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Main Authors | , , , |
Format | Journal Article |
Language | Japanese |
Published |
Japan
Japan Antibiotics Research Association
01.11.1992
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Subjects | |
Online Access | Get full text |
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Summary: | Laboratory and clinical studies were done on cefprozil (CFPZ, BMY-28100). The results are summarized as follows. CFPZ was administered through the oral route to 2 children at a single dose of 7.5mg/kg. After administration, peak serum levels of CFPZ obtained in the 2 cases were 6.71 μg/ml at 1 hour and 6.45 μg/ml at 2 hours, respectively and half-lives were 1.28 hours and 0.92 hour, respectively. The urinary excretion rates of CFPZ were 58.9% and 59.4%, respectively. Treatment with CFPZ was made in 37 cases of pediatric bacterial infections: 1 case of pharyngitis, 16 cases of tonsillitis, 16 cases of scarlet fever, 3 cases of impetigo, 1 case of UTI. Results obtained were excellent in 24 cases, good in 13 cases. No significant side effects due to the drug were observed, except 1 case of loose stool, 3 cases of eosinophilia, and 1 case each of elevated GOT and GPT. |
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ISSN: | 0368-2781 2186-5477 |
DOI: | 10.11553/antibiotics1968b.45.1582 |