CLINICAL STUDIES OF CEFOTAXIME ON INFECTIONS IN INTERNAL MEDICINE

Clinical studies on a new cephalosporin antibiotic, cefotaxime (CTX) were carried out in 79 patients with various types of infections in internal medicine. The efficacy rates were 65.8% in 39 cases of respiratory tract infections, 94.1% in 17 cases of biliary tract infections, 75.0% in 12 cases of u...

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Published inJapanese journal of antibiotics Vol. 37; no. 9; pp. 1714 - 1728
Main Authors KAWASAKI, HIRONAKA, SUOU, TAKEAKI, WATANABE, KAZUHIKO, YOSHIDA, KATSUHIKO, SASAKI, HIROYUKI, KISHIMOTO, YUKIHIRO, SUGIHARA, TETSUHIKO, ISHITOBI, SEIICHI, KANNO, SEIJI, TSURUHARA, ICHIROU, WAKUSHIMA, TADASHI, KOJOU, HARUHIKO
Format Journal Article
LanguageJapanese
Published Japan Japan Antibiotics Research Association 01.09.1984
Subjects
Adult
Aged
Bacterial Infections - drug therapy
Cefotaxime - administration & dosage
Cefotaxime - adverse effects
Cefotaxime - therapeutic use
Drug Evaluation
Female
Humans
Infusions, Parenteral
Injections, Intravenous
Male
Middle Aged
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Summary:Clinical studies on a new cephalosporin antibiotic, cefotaxime (CTX) were carried out in 79 patients with various types of infections in internal medicine. The efficacy rates were 65.8% in 39 cases of respiratory tract infections, 94.1% in 17 cases of biliary tract infections, 75.0% in 12 cases of urinary tract infections, 80.0% in 11 cases of other infections, and 75.3% in all cases. After CTX therapy, body temperature was improved in 76.7% of all 79 patients, particularly being excellent in all cases of biliary tract infections. Furthermore, symptoms such as cough, dyspnea, chest pain, moist rale and anorexia were improved to a great degree after CTX therapy. Adverse reactions and abnormal laboratory findings consisted of mild liver injury in 1 out of 79 cases. CTX was assessed to be an effective antibiotic for various types of infections in internal medicine.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.37.1714