主観的well-being制御に関わる分子を血液中から探索する

• Published in: 日本薬理学会年会要旨集 p. 2-B-SS12-7
• Main Authors: 東山, 綾花, 稲田, 祐奈, 東田, 千尋
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2023
• Subjects: aging; behavior; plasma; protein
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.97.0_2-B-SS12-7

Subjective well-being (SWB) is an important research topic being addressed from a variety of perspectives, including psychology, public health and medicine. SWB is influenced by physical activity and cognitive activity, and vice versa SWB affects physical activity and cognitive activity, suggesting that the locomotor system and the brain are closely related to SWB. However, the molecular basis of these interactions has not been clarified. This study aimed to find responsible molecules to control SWB from the blood circulation connecting the locomotor system and the brain. In experiment 1, we conducted a clinical human study to explore molecules increased SWB level-dependently in plasma. Subjective were healthy elderly people aged 65 and over. To elucidate features of elder people with high SWB, subjects were divided into 4 groups by their SWB scores, plasma proteins in 4 groups were comprehensively compared by analysis. As results, the level of protein X increased in high SWB subjects. In experiment 2, mice were bred in enriched environment or stressful environment for 8 weeks to boost positive or negative emotion. Expression levels of protein X in the brain, the skeletal muscle and plasma are quantified. Functional roles of protein X in those organs are also under investigation.