ミクログリアが脳梗塞の海馬歯状回顆粒細胞の樹状突起スパインに与える影響

Microglia contribute to synaptic pruning by synaptic engulfment, which is dependent on neuronal activity. Our middle cerebral artery occlusion (MCAO) mice show an upregulation of neuronal activity in the hippocampal dentate gyrus (DG). Thus, we investigated the changes in dendritic spines in DG gran...

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Published in日本薬理学会年会要旨集 p. 2-B-SS08-2
Main Authors 岡田, 桃花, 中澤, 秀真, 髙橋, 瞳, 山口, 菜摘, 中谷, 仁, 澤野, 俊憲, 田中, 秀和
Format Journal Article
LanguageJapanese
Published 公益社団法人 日本薬理学会 2023
Subjects
dentate gyrus
ischemia
microglia
synapse
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Summary:Microglia contribute to synaptic pruning by synaptic engulfment, which is dependent on neuronal activity. Our middle cerebral artery occlusion (MCAO) mice show an upregulation of neuronal activity in the hippocampal dentate gyrus (DG). Thus, we investigated the changes in dendritic spines in DG granule cells following cerebral ischemia and microglial contribution to it. We showed that the number of dendritic spines of DG granule cells in MCAO mice was lower than that in sham mice. However, microglial depletion with CSF1R inhibitor (PLX3397) inhibited the MCAO-induced reduction of the dendritic spine. These results suggest that microglia are involved in the decrease in the number of dendritic spines of DG granule cells following cerebral ischemia.
Bibliography:97_2-B-SS08-2
ISSN:2435-4953
DOI:10.1254/jpssuppl.97.0_2-B-SS08-2