A juxtaglomerular cell tumor. Analysis of immunohistochemistry, electron microscopy and in situ hybridization

We present a case of juxtaglomerular cell tumor measuring 8 mm in diameter in the right kidney. The hypertension was cured and plasma renin activity returned to normal level following tumor resection with partial nephrectomy. We studied histopathologic, electron microscopic, and immunohistochemical...

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Bibliographic Details
Published inNippon Hinyokika Gakkai zasshi Vol. 89; no. 11; p. 907
Main Authors Hashimoto, Y, Nakazawa, H, Okuda, H, Ito, F, Onizuka, S, Kihara, K, Suzuki, M, Maeda, Y, Toma, H
Format Journal Article
LanguageJapanese
Published Japan 01.11.1998
Subjects
Adenocarcinoma - metabolism
Adenocarcinoma - surgery
Adenocarcinoma - ultrastructure
Adult
Humans
Immunohistochemistry
In Situ Hybridization
Kidney Neoplasms - metabolism
Kidney Neoplasms - surgery
Kidney Neoplasms - ultrastructure
Male
Nephrectomy
Renin - analysis
RNA Probes
RNA, Messenger - analysis
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Summary:We present a case of juxtaglomerular cell tumor measuring 8 mm in diameter in the right kidney. The hypertension was cured and plasma renin activity returned to normal level following tumor resection with partial nephrectomy. We studied histopathologic, electron microscopic, and immunohistochemical findings of the tumor. The majority of tumor cells stores renin granules in cytoplasm. In situ hybridization confirmed us that the most tumor cells produce renin. We use the digoxigenin labeled 0.6-kb length RNA probe of human renal renin, the specificity was analyzed by competition assay (1:50).
ISSN:0021-5287
DOI:10.5980/jpnjurol1989.89.907