Preparation of Ethanolamine Oleate Injection Mixed with Contrast Medium

• Published in: Japanese Journal of Hospital Pharmacy Vol. 12; no. 5; pp. 385 - 389
• Main Authors: ITAKURA, TADANORI, MABUCHI, KAZUHIDE, KATAGIRI, YOSHIHIRO, AKIYAMA, MIKI, NOZU, YOSHIMASA, YAMAMOTO, SHUN, KAWAI, TOSHIO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Pharmaceutical Health Care and Sciences 1986
• Subjects: contrast medium; esophageal varix; ethanolamine oleate; injection sclerotherapy; iopamidol; meglumine amidotrizoate; osmotic pressure; sclerosing agent; viscosity
• ISSN: 0389-9098; 2185-9477
• DOI: 10.5649/jjphcs1975.12.385

Ethanolamine oleate injection has been used as a sclerosing agent in the treatment of esophageal varices. We prepared 4 kinds of sclerosing agents for visualizing varices by mixing ethanolamine oleate with contrast media, iopamidol and meglumine amidotrizoate injections. The viscosities and osmotic pressures of these agents were measured. The time required to discharge a given volume of each agent through a syringe, a tube and a puncture needle under the pressure of 2 kg/ 2. 6 cm2 was measured. The ability of visualization was observed by X-ray fluoroscopy. Ethanolamine oleate injection containing 30% iopamidol (EO-IP30) was less viscous. Furthermore, the value of osmotic.pressure of EO-IP30 was almost the same as that of normal saline. The viscosity of the agent was related to the time required discharge a given volume of the agent. The time for a discharge of EO-IP30 was shortest. Good fluoroscopic visualization was obtained in all preparations. These results suggest that EO-IP30 is a usefulagent for injection sclerotherapy of esophageal varices.