POSTANTIBIOTIC EFFECTS (PAE'S) OF MACROLIDE ANTIBIOTICS EVALUATED USING BIOSCREEN C METHOD

• Published in: Japanese journal of antibiotics Vol. 48; no. 4; pp. 548 - 552
• Main Authors: OKUBO, TOYOJI, SUZUKI, TAKAO, FUJITA, KIN-ICHI, IYOBE, SHIZUKO, INOUE, MATSUHISA
• Format: Journal Article
• Language: Japanese
• Published: Japan Japan Antibiotics Research Association 01.04.1995
• Subjects: Anti-Bacterial Agents - pharmacology; Bacteria - drug effects; Bacteria - growth & development; Bacteriological Techniques; Cell Count; Cell Survival; Enterococcus faecalis - drug effects; Enterococcus faecalis - growth & development; Erythromycin - pharmacology; Josamycin - pharmacology; Miocamycin - analogs & derivatives; Miocamycin - pharmacology; Staphylococcus aureus - drug effects; Staphylococcus aureus - growth & development
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.48.548

Postantibiotic effects (PAE's) of macrolide antibiotics were determined for Staphylococcus aureus and Enterococcus faecalis using viable counting and Bioscreen C method and the two methods were compared. No major differences between the two methods were observed. The Bioscreen C method was less laborious than the viable counting. The durations of PAE for S. aureus following exposures to erythromycin (EM), josamycin (JM) and rokitamycin (RKM) for 2 hours at twice the MICs were in ranges of 0.85 to 1.45, 2.36 to 3.48 and 1.93 to 5.45 hours, respectively. A definite PAE of 1.0 to 5.8 hou rs was also observed in E. faecalis strains exposed for 2 hours to EM, JM and RKM at twice the MICs.