A case of Turner syndrome (46XXp-/45X) complicated with Crohn's disease after hormone therapy

A 19-year-old woman, who had been receiving hormone replacement therapy for 13 months before the diagnosis of mosaic Turner syndrome (46XXp-/45X), developed Crohn's colitis and erythema nodosum of the lower legs. Colonoscopy revealed an anal fistula and the presence of deep longitudinal ulcers...

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Published inNippon Shōkakibyō Gakkai zasshi Vol. 114; no. 3; p. 445
Main Authors Ihara, Yutaro, Hizawa, Kazuoki, Fujita, Kouhei, Iida, Masahiro, Washio, Ema, Kai, Takahiro, Nitahata, Tomoki, Esaki, Motohiro, Iida, Mitsuo
Format Journal Article
LanguageJapanese
Published Japan 2017
Subjects
Chromosomes, Human, X
Colonoscopy
Crohn Disease - diagnostic imaging
Crohn Disease - etiology
Female
Hormone Replacement Therapy - adverse effects
Humans
Tomography, X-Ray Computed
Turner Syndrome - complications
Turner Syndrome - drug therapy
Young Adult
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Summary:A 19-year-old woman, who had been receiving hormone replacement therapy for 13 months before the diagnosis of mosaic Turner syndrome (46XXp-/45X), developed Crohn's colitis and erythema nodosum of the lower legs. Colonoscopy revealed an anal fistula and the presence of deep longitudinal ulcers with cobblestoning in the colorectum. Therapy with prednisolone and adalimumab was effective for the intestinal and skin lesions. To date, all seven case reports of Turner syndrome in Japan have also developed Crohn's disease after hormone therapy, suggesting a possible association of sex hormones in the pathogenesis.
ISSN:0446-6586
DOI:10.11405/nisshoshi.114.445