PHARMACOKINETIC AND CLINICAL STUDIES OF CEFODIZIME IN THE FIELD OF OBSTETRICS AND GYNECOLOGY

Cefodizime (THR-221, CDZM), a new antibiotic, was studied pharmacokinetically and clinically. The results obtained are summarized as follows: 1. Concentrations of CDZM in internal genital tissues were quite high after an intravenous infusion. 2. Clinical effects of the therapy with CDZM using intrav...

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Published inJapanese journal of antibiotics Vol. 42; no. 1; pp. 208 - 211
Main Authors IIOKA, HIDEAKI, MORIYAMA, IKUKO, NABUCHI, KAORU, KATAGAMI, YOSHIAKI, HISANAGA, HIROYASU, TUJI, YOSHIMASA, ICHIJO, MOTOHIKO
Format Journal Article
LanguageJapanese
Published Japan Japan Antibiotics Research Association 1989
Subjects
Adult
Bacterial Infections - drug therapy
Cefotaxime - analogs & derivatives
Cefotaxime - pharmacokinetics
Cefotaxime - therapeutic use
Drug Evaluation
Drug Tolerance
Female
Genital Diseases, Female - drug therapy
Genital Diseases, Female - metabolism
Genitalia, Female - metabolism
Humans
Middle Aged
Pregnancy
Pregnancy Complications, Infectious - drug therapy
Tissue Distribution
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Summary:Cefodizime (THR-221, CDZM), a new antibiotic, was studied pharmacokinetically and clinically. The results obtained are summarized as follows: 1. Concentrations of CDZM in internal genital tissues were quite high after an intravenous infusion. 2. Clinical effects of the therapy with CDZM using intravenous infusion twice daily were evaluated in 1 patient with endometritis, 2 patients with pyometra, 1 patient with extragenital abscess and 1 patient with BARTHOLIN'S gland abscess. Clinical responses were good in all 5 patients. No side effects nor abnormal laboratory test values due to the drug were noted.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.42.208