Establishment of a continuous cell line from fibrotic schistosomal granulomas in mice livers

A continuous murine cell line (GRX) was obtained from fibrotic granulomas induced in C3H/HeN mice liver by experimental infection with Schistosoma mansoni. This anchorage-dependent line produces composite connective tissue/extracellular matrix, displays morphological characteristics of myofibroblast...

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Bibliographic Details
Published inIn vitro cellular & developmental biology Vol. 21; no. 7; p. 382
Main Authors Borojevic, R, Monteiro, A N, Vinhas, S A, Domont, G B, Mourão, P A, Emonard, H, Grimaldi, Jr, G, Grimaud, J A
Format Journal Article
LanguageEnglish
Published United States 01.07.1985
Subjects
Animals
Cell Differentiation
Cell Division
Cell Line
Cell Membrane - ultrastructure
Clone Cells - pathology
Cytoplasm - ultrastructure
Extracellular Matrix - metabolism
Female
Granuloma - genetics
Granuloma - metabolism
Granuloma - pathology
Karyotyping
Lipid Metabolism
Liver Diseases, Parasitic - genetics
Liver Diseases, Parasitic - metabolism
Liver Diseases, Parasitic - pathology
Lymphocytes - pathology
Macrophages - pathology
Male
Mice
Mice, Inbred C3H
Microscopy, Electron, Scanning
Schistosoma mansoni
Schistosomiasis - genetics
Schistosomiasis - metabolism
Schistosomiasis - pathology
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Summary:A continuous murine cell line (GRX) was obtained from fibrotic granulomas induced in C3H/HeN mice liver by experimental infection with Schistosoma mansoni. This anchorage-dependent line produces composite connective tissue/extracellular matrix, displays morphological characteristics of myofibroblasts, and can, under appropriate conditions, accumulate fat droplets. GRX cells produce viral particles of retrovirus type. We consider GRX cell line to be representative of liver connective tissue cells, responsible for fibroplasia in liver fibrotic and granulomatous reactions.
ISSN:0883-8364