Development of a spheroid-permeable polymer

Spheroids have attracted much attention in medical research as a tool to understand both disease mechanisms and drug actions in culture. Cell-cell and/or cell-extracellular matrices interactions seen in spheroids allow cells to mimic in vivo cellular microenvironments, resulting in recapitulating in...

Full description

Saved in:
Bibliographic Details
Published inDrug Delivery System Vol. 36; no. 4; pp. 248 - 255
Main Authors Yamamoto, Masaya, Morimoto, Nobuyuki
Format Journal Article
LanguageJapanese
Published Kawasaki THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 2021
Japan Science and Technology Agency
Subjects
Anticancer properties
Antineoplastic drugs
Antitumor activity
Antitumor agents
Cancer
cell aggregate
Cell culture
Conjugation
Drugs
Medical research
Microenvironments
Permeability
Polymers
spheroid
spheroid-permeable polymer
Spheroids
sulfobetaine polymer
Online AccessGet full text

Cover

More Information
Summary:Spheroids have attracted much attention in medical research as a tool to understand both disease mechanisms and drug actions in culture. Cell-cell and/or cell-extracellular matrices interactions seen in spheroids allow cells to mimic in vivo cellular microenvironments, resulting in recapitulating in vivo-like cell functions in culture. However, the microenvironments could also function as a barrier to deliver drugs to cells in spheroids. To tackle this drawback, a sulfobetaine polymer was developed as a spheroid-permeable polymer. In this article, the enhanced anticancer activity of anticancer drugs by conjugation with the spheroid-permeable polymer was introduced.
ISSN:0913-5006
1881-2732
DOI:10.2745/dds.36.248