Influence of Gradual Loading on Disuse Atrophy of the Rat Soleus Muscle Depends on the Longitudinal Site

[Purpose] The purpose of this study was to verify the recovery after disuse atrophy by gradual loading. [Participants and Methods] Eight-week-old male Wistar rats were randomly assigned to control, hind-limb suspension (H), gradual loading after 7 days of hind-limb suspension (G), and constant loadi...

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Bibliographic Details
Published inRigaku ryoho kagaku Vol. 34; no. 1; pp. 13 - 16
Main Authors TANIGUCHI, Hirotaka, ZUSHI, Kazumi, YAMAZAKI, Toshiaki
Format Journal Article
LanguageJapanese
Published Tokyo The Society of Physical Therapy Science 2019
Japan Science and Technology Agency
Subjects
disuse atrophy
gradual loading
Rodents
soleus muscle
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Summary:[Purpose] The purpose of this study was to verify the recovery after disuse atrophy by gradual loading. [Participants and Methods] Eight-week-old male Wistar rats were randomly assigned to control, hind-limb suspension (H), gradual loading after 7 days of hind-limb suspension (G), and constant loading after 7 days of hind-limb suspension (W) groups. At the end of the experimental period, the cross-sectional area and occurrence ratio of necrotic and central nuclear fibers were measured. [Results] The cross-sectional areas of the muscle fibers in the proximal region of the H and W groups were significantly smaller than those of the other groups, but there was no site-dependent difference in G group. [Conclusion] The results suggest gradual loading is an effective intervention for the proximal region which is the region most susceptible to disuse atrophy.
ISSN:1341-1667
2434-2807
DOI:10.1589/rika.34.13