Case of scattered gastritis associated with ulcerative proctitis

• Published in: Nippon Shōkakibyō Gakkai zasshi Vol. 106; no. 1; p. 61
• Main Authors: Ozawa, Toshifumi, Wachi, Eiko, Saitoh, Yasutoshi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.01.2009
• Subjects: Aminosalicylic Acids - administration & dosage; Drug Therapy, Combination; Gastritis - drug therapy; Gastritis - etiology; Gastritis - pathology; Humans; Male; Middle Aged; Prednisolone - administration & dosage; Proctocolitis - complications; Treatment Outcome
• ISSN: 0446-6586
• DOI: 10.11405/nisshoshi.106.61

A 59-year-old man who had ulcerative proctitis for 18 years visited our hospital because of stomach pain. Proctitis had been in remission stage for five recent years by the mesalazine administration. Esophagogastroduodenoscopy (EGD) showed scattered patchy erosions at the corpus of the stomach. Anti-acid secretory agents was administrated, however, erosive change worsened in multiplicity and in area. Biopsied specimen of gastric mucosa showed specific findings resembling to cryptitis, crypt abcess and focally enhanced gastritis. H. pylori infection was negative by some examinations. Our patient had no history of taking non steroidal anti-inflammatory drugs (NSAIDs) so far. From the findings above, it was considered that gastric lesion was strongly related to the ulcerative proctitis. 5-aminosalicylic acid (750 mg, three times daily) ground to powder was administered with predonisolon (20 mg, once daily). Five month later, all the erosions disappeared completely on EGD and biopsied specimen revealed a reduction of inflammatory cells. The present case has a rare gastric lesion with patchy pattern (not diffuse pattern) which is strongly associated with ulcerative proctitis.