Clinical Pathophysiological Characteristics and Immunohistochemistry of β-catenin Protein and p53 Protein, and Analysis on Microsatellite Instability in Colorectal Laterally Spreading Tumors

• Published in: The Japanese Journal of Gastroenterological Surgery Vol. 35; no. 2; pp. 135 - 143
• Main Authors: Matsumoto, Yoshiro, Eguchi, Hideo, Yamada, Haruki, Iino, Hiroshi, Fujii, Hideki, Hasegawa, Hiromasa
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society of Gastroenterological Surgery 2002
• Subjects: colorectal laterally spreading tumor; microsatellite instability; p53 protein; β-catenin protein
• ISSN: 0386-9768; 1348-9372
• DOI: 10.5833/jjgs.35.135

Aims: We studied clinical pathophysiological characteristics and the tumorigenic and carcinogenic process from immunohistochemistry of β-catenin protein and p53 protein and microsatellite instability (MSI) analysis in 31 lesions in 31 patients of laterally spreading tumor (LST) of the large intestine. Results: LSTs were divided into three groups, of which Granular-Homogenous (G-H), Granular-Nodular mixed (G-N) and Non Granular (NG). The rate of involving cancer was significantly higher in group G-N and NG than in group G-H, particularly in group NG, in which all tumors with a diameter of less than 20 mm were cancerous. The incidence of p53 protein increased as heteromorphism advanced. The incidence of β-catenin protein was high in the nucleus and cytoplasm regardless of heteromorphism. We saw no MSI-H (igh) case. Conclusions: 1) group NG was high in biological malignancy. 2) β-catenin protein played a role in LST tumorigenesis. 3) The carcinogenic process was principally LOH. 4) LST was not one distinct concept-disease.