ニューロフィードバックシステムによる海馬シータ位相歳差の誘導

• Published in: 日本薬理学会年会要旨集 p. 2-P1-06
• Main Authors: 青木, 勇樹, 池谷, 裕二, 佐々木, 拓哉
• Format: Journal Article
• Language: Japanese
• Published: 公益社団法人 日本薬理学会 2021
• Subjects: hippocampus
• ISSN: 2435-4953
• DOI: 10.1254/jpssuppl.94.0_2-P1-06

The hippocampus plays an important role in the processing of spatial memory by sequential activation of neuronal ensembles. Sequential activity occurs at different time scales between behavioral and sleep states. In a behavioral state, as animals explore an environment, hippocampal place cells are sequentially activated in response to their ongoing trajectory, which is time-locked to theta oscillations In a subsequent sleep state, same place cells are sequentially reactivated at a faster time scale within tens of milliseconds. The reactivation of place cells occurs during the high-frequency oscillations, the sharp-wave ripple, which is thought to play an important role in memory consolidation. However, it remains unclear how sequential activity is maintained across these different time scales. To address this issue, we designed a novel neurofeedback stimulation protocol to selectively induce theta phase precession in a subset of neurons. We now apply this protocol during behavioral state and analyze how subsequent reactivation events are altered. Our data will provide a new insight into the mechanisms of sequential activity of hippocampal cells underlying information processing.