BNCTの線量評価／治療計画
BNCTの線量評価は，まずホウ素(10B)と中性子との反応によって生じるホウ素線量を評価する。さらに生体組織を構成する窒素や水素と中性子との反応で生じる線量や，ビームに混入するγ線による付随線量も評価しなければならない。中性子の粒子挙動は複雑であるため，BNCTの線量評価にはモンテカルロ法が用いられる。したがってBNCT用の治療計画システムには開発当初からモンテカルロ線量計算エンジンが実用化されている。...
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| Published in | RADIOISOTOPES Vol. 64; no. 1; pp. 37 - 46 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
公益社団法人 日本アイソトープ協会
2015
|
| Online Access | Get full text |
| ISSN | 0033-8303 1884-4111 |
| DOI | 10.3769/radioisotopes.64.37 |
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| Abstract | BNCTの線量評価は，まずホウ素(10B)と中性子との反応によって生じるホウ素線量を評価する。さらに生体組織を構成する窒素や水素と中性子との反応で生じる線量や，ビームに混入するγ線による付随線量も評価しなければならない。中性子の粒子挙動は複雑であるため，BNCTの線量評価にはモンテカルロ法が用いられる。したがってBNCT用の治療計画システムには開発当初からモンテカルロ線量計算エンジンが実用化されている。 |
|---|---|
| AbstractList | BNCTの線量評価は，まずホウ素(10B)と中性子との反応によって生じるホウ素線量を評価する。さらに生体組織を構成する窒素や水素と中性子との反応で生じる線量や，ビームに混入するγ線による付随線量も評価しなければならない。中性子の粒子挙動は複雑であるため，BNCTの線量評価にはモンテカルロ法が用いられる。したがってBNCT用の治療計画システムには開発当初からモンテカルロ線量計算エンジンが実用化されている。 |
| Author | 熊田, 博明 |
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| Copyright | 2015 by Japan Radioisotope Association |
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| DOI | 10.3769/radioisotopes.64.37 |
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| References | 13) Tanaka, H. et al., Experimental verification of beam characteristics for cyclotron-based epithermal neutron source(C-BENS), Appl. Radiat. Iso., 69, 1642-1645(2011 11) Kumada, H. et al., Improvement of dose calculation accuracy for BNCT dosimetry by the multi-voxel method in JCDS, Appl. Radiat. Iso., 61, 1045-1050(2004 6) Zamenhof, R. G. et al., Monte Carlo based treatment planning for boron neutron capture therapy using custom designed models automatically generated from CT data, Int. J. Radiat. Oncol. Biol. Phys., 32, 383-397(1996 7) Yu, H.T. et al., BNCT treatment planning system of recurrent head-and-neck cancer using THORplan, Appl. Radiat. Iso., 69, 1907-1910(2011 9) Briesmeister, J. F., MCNPTM- A General Monte Carlo N-Particle Transport Code, LA-13709-M，(2000 4) Kumada, H. et al., Verification of the computational dosimetry system in JAERI(JCDS) for boron neutron capture therapy, Phys. Med. Biol., 49, 3353-3365(2004 12) Kumada, H. et al., Development of JCDS, a computational dosimetry system at JAEA for boron neutron capture therapy, J. Phys. Conf. Ser., 74, 1-7(2007 5) Nigg, D. W. et al., SERA- an advanced treatment planning system for neutron therapy and BNCT, Trans. Am. Nus. Soc., 80, 66(1999 8) Kumada, H. et al., Project for the development of the linac based NCT facility in University of Tsukuba, Appl. Radiat. Iso., 88, 211-215(2014 1) Capala, J. et al., Accumulation of boron in malignant and normal cells incubated in vitro with boronophenylalanine, mercaptoborane or boric acid, Radiat. Res., 146, 554-560(1996 2) Kobayashi, T. and Kanda, K., Analytical calculation of boron-10 dosage in cell nucleus for neutron capture therapy, Radiation Research, 91(1), 77-94(1982 3) Kawabata, S. et al., Boron neutron capture therapy for newly diagnosed glioblastoma, J. Radiat. Res., 50, 51-60(2009 10) Iwase, H. et al., Development of general-purpose particle and heavy ion transport Monte-Carlo code, J. Nucl. Sci. Technol., 39, 1142-1151(2002 |
| References_xml | – reference: 2) Kobayashi, T. and Kanda, K., Analytical calculation of boron-10 dosage in cell nucleus for neutron capture therapy, Radiation Research, 91(1), 77-94(1982) – reference: 7) Yu, H.T. et al., BNCT treatment planning system of recurrent head-and-neck cancer using THORplan, Appl. Radiat. Iso., 69, 1907-1910(2011) – reference: 11) Kumada, H. et al., Improvement of dose calculation accuracy for BNCT dosimetry by the multi-voxel method in JCDS, Appl. Radiat. Iso., 61, 1045-1050(2004) – reference: 8) Kumada, H. et al., Project for the development of the linac based NCT facility in University of Tsukuba, Appl. Radiat. Iso., 88, 211-215(2014) – reference: 10) Iwase, H. et al., Development of general-purpose particle and heavy ion transport Monte-Carlo code, J. Nucl. Sci. Technol., 39, 1142-1151(2002) – reference: 3) Kawabata, S. et al., Boron neutron capture therapy for newly diagnosed glioblastoma, J. Radiat. Res., 50, 51-60(2009) – reference: 5) Nigg, D. W. et al., SERA- an advanced treatment planning system for neutron therapy and BNCT, Trans. Am. Nus. Soc., 80, 66(1999) – reference: 9) Briesmeister, J. F., MCNPTM- A General Monte Carlo N-Particle Transport Code, LA-13709-M，(2000) – reference: 13) Tanaka, H. et al., Experimental verification of beam characteristics for cyclotron-based epithermal neutron source(C-BENS), Appl. Radiat. Iso., 69, 1642-1645(2011) – reference: 1) Capala, J. et al., Accumulation of boron in malignant and normal cells incubated in vitro with boronophenylalanine, mercaptoborane or boric acid, Radiat. Res., 146, 554-560(1996) – reference: 12) Kumada, H. et al., Development of JCDS, a computational dosimetry system at JAEA for boron neutron capture therapy, J. Phys. Conf. Ser., 74, 1-7(2007) – reference: 6) Zamenhof, R. G. et al., Monte Carlo based treatment planning for boron neutron capture therapy using custom designed models automatically generated from CT data, Int. J. Radiat. Oncol. Biol. Phys., 32, 383-397(1996) – reference: 4) Kumada, H. et al., Verification of the computational dosimetry system in JAERI(JCDS) for boron neutron capture therapy, Phys. Med. Biol., 49, 3353-3365(2004) |
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| Title | BNCTの線量評価／治療計画 |
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