Successful treatment with high dose chemotherapy following peripheral blood stem cell transplantation for relapsed Burkitt's lymphoma with central nervous system involvement

• Published in: Rinshō ketsueki Vol. 39; no. 11; p. 1121
• Main Authors: Yamao, H, Kondo, E, Miura, A, Mizuno, H, Yuge, M
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.11.1998
• Subjects: Adult; Anti-Inflammatory Agents - administration & dosage; Antimetabolites, Antineoplastic - administration & dosage; Antineoplastic Agents, Alkylating - administration & dosage; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Burkitt Lymphoma - therapy; Carboplatin - administration & dosage; Carboplatin - therapeutic use; Central Nervous System Neoplasms - therapy; Cyclophosphamide - administration & dosage; Cyclophosphamide - therapeutic use; Cytarabine - administration & dosage; Cytarabine - therapeutic use; Dexamethasone - administration & dosage; Dexamethasone - therapeutic use; Etoposide - administration & dosage; Etoposide - therapeutic use; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide - administration & dosage; Ifosfamide - therapeutic use; Male; Transplantation, Autologous
• ISSN: 0485-1439
• DOI: 10.11406/rinketsu.39.1121

A 19-year-old man complaining of right upper abdominal pain underwent surgery for the removal of a testicular tumor in October 1997. He was given a diagnosis of Burkitt's lymphoma and was in clinical stage II B. The patient went into completed remission with VABCOP-M combination chemotherapy, but relapsed with involvement of the central nervous system (CNS). He was treated with ICE, then CHASE together with total cranial irradiation and simultaneous intrathecal MTX and cytosine arabinoside through Ommaya reservoir until a second remission was achieved. Afterward, the patient was given high-dose chemotherapy and total body irradiation followed by an autologous peripheral blood stem cell transplant (auto-PBSCT), and maintained complete remission. Though the prognosis for Burkitt's lymphoma with CNS involvement is considered to be poor, high-dose chemotherapy with PBSCT was a successful treatment for relapsed Burkitt's lymphoma in our patient.