Successful treatment with CHOP therapy for progressive of primary macroglobulinemia without further increase of serum IgM

• Published in: Rinshō ketsueki Vol. 46; no. 7; p. 536
• Main Authors: Wakimoto, Naoki, Misumi, Motohiro, Maeda, Tomoya, Shimada, Tsuneyuki, Wakao, Daisuke, Sato, Yasutaka, Takahashi, Naoki, Sugahara, Yuichi, Yoshida, Katsuhiko, Yagasaki, Fumiharu, Ito, Yoshihiro, Nakamura, Yuichi, Kawai, Nobutaka, Matsuda, Akira, Jinnai, Itsuro, Bessho, Masami
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.07.2005
• Subjects: Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomarkers - blood; Cyclophosphamide - administration & dosage; Disease Progression; Doxorubicin - administration & dosage; Humans; Immunoglobulin M - blood; Male; Middle Aged; Prednisolone - administration & dosage; Treatment Outcome; Vincristine - administration & dosage; Waldenstrom Macroglobulinemia - diagnosis; Waldenstrom Macroglobulinemia - drug therapy
• ISSN: 0485-1439
• DOI: 10.11406/rinketsu.46.536

A 61-year-old man with primary macroglobulinemia (PMG) had been followed without any treatment as he had no apparent manifestations. After 1 year and 3 months, he was admitted to our hospital with a fever. No signs or symptoms of infection and no progressive increase of serum IgM levels was observed. Non-Hodgkin's lymphoma was not additionally found. Fever without infection, elevated serum LDH level and further enlargement of the spleen compelled us to diagnose his condition as deterioration of the PMG. An immediate fall in his temperature and serum IgM levels was observed after CHOP therapy. Effective therapy must be discussed in the deterioration of this type of disease.