Studies on the Mixing of Pharmaceutical Powders. I

The mixing degree of pharmaceutical powders was evaluated on the mixture of salicylic acid sieved into 5 classes and the diluent, potato starch. The mixers employed were Cube- and V-type, and the mixing ratios were varied from 1 : 10 to 1 : 5000. The coefficient of variation was used as a mixing ind...

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Published inYAKUGAKU ZASSHI Vol. 88; no. 7; pp. 827 - 831
Main Authors OKADA, JUTARO, MATSUDA, YOSHIHISA, MORITA, SHUSHI, WADA, YASUTAKA, OHNISHI, HARUO
Format Journal Article
LanguageJapanese
Published Japan The Pharmaceutical Society of Japan 01.07.1968
Subjects
Drug Compounding
Mathematics
Powders
Salicylates
Starch
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Summary:The mixing degree of pharmaceutical powders was evaluated on the mixture of salicylic acid sieved into 5 classes and the diluent, potato starch. The mixers employed were Cube- and V-type, and the mixing ratios were varied from 1 : 10 to 1 : 5000. The coefficient of variation was used as a mixing index and the results were compared with the theoretical value by Stange's equation. Furthermore, considering from the coefficient of variation, dilution ratio and the size of active ingredient, following experimental equation was derived obtained.σ/co =2.08×10-4(1/co)0.394(d^-)0.485 where, σ/co : coefficent of variation [%] 1/co : dilution rario [-] d^- : mean particle diameter of active ingredient [μ]
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.88.7_827