Transient chromosomal abnormalities following autologous peripheral blood stem cell transplantation for acute myelogenous leukemia

Twenty-three patients with acute myelogenous leukemia (AML) have received autologous hematopoietic stem cell transplantation (autoHSCT) in our institute from 1997 to 2005. Among them, 3 patients relapsed, and the other 4 patients (17%) showed cytogenetic abnormalities after the autoHSCT. In these 4...

Full description

Saved in:
Bibliographic Details
Published inRinshō ketsueki Vol. 48; no. 8; p. 618
Main Authors Usuki, Kensuke, Nakasone, Hideki, Taoka, Kazuki, Kida, Michiko, Iki, Seiko, Urabe, Akio
Format Journal Article
LanguageJapanese
Published Japan 01.08.2007
Subjects
Adolescent
Adult
Chromosome Aberrations
Female
Humans
Leukemia, Myeloid, Acute - therapy
Male
Middle Aged
Peripheral Blood Stem Cell Transplantation - adverse effects
Online AccessGet more information

Cover

More Information
Summary:Twenty-three patients with acute myelogenous leukemia (AML) have received autologous hematopoietic stem cell transplantation (autoHSCT) in our institute from 1997 to 2005. Among them, 3 patients relapsed, and the other 4 patients (17%) showed cytogenetic abnormalities after the autoHSCT. In these 4 patients with AML1/MTG8 or CBFbeta/MYH11 AML, RT-PCR findings using bone marrow cells were all negative when a cytogenetic abnormality was detected. Myelodysplasia was not detected in the bone marrow and no abnormal findings were seen in the peripheral blood. Cytogenetic abnormalities were detected 12-48 months after AutoHSCT, which disappeared in three patients and decreased in the remaining one patient with a median follow up time of 51 months (30-72 months) after their detection. We present our finding together with a review of the literature on post-autoHSCT cytogenetic abnormalities not related to relapse or secondary leukemia/myelodysplastic syndrome.
ISSN:0485-1439
DOI:10.11406/rinketsu.48.618