小線量γ線のマウス生体内抗酸化系酵素活性に対する作用

小線量放射線の生体内抗酸化系酵素に対する作用を検討する目的で, 雌性C57BL/6マウス (7週齢) に137Cs線源 (1.24Gy/min) からのγ線を50cGy全身照射し, 経時的に脳および肝臓でのスーパーオキサイドジスムターゼ (SOD) およびカタラーゼ (CAT) の活性変化を24時間後まで検討した。この結果, Cu/Zn-SODは脳および肝臓で照射後早い時期 (12時間以内) に活性上昇がみられ, とりわけ脳で顕著であった。一方Mn-SODは, 脳では顕著な活性変化がみられず, 肝臓では反対に活性低下がみられた。CATについては, いずれの臓器でも, 照射後12時間までに活性上...

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Published inRADIOISOTOPES Vol. 47; no. 4; pp. 291 - 299
Main Authors 久保寺, 昭子, 山岡, 聖典, 野村, 崇治, 小島, 周二, 松木, 修
Format Journal Article
LanguageJapanese
Published 公益社団法人 日本アイソトープ協会 15.04.1998
Online AccessGet full text
ISSN0033-8303
1884-4111
DOI10.3769/radioisotopes.47.291

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Abstract 小線量放射線の生体内抗酸化系酵素に対する作用を検討する目的で, 雌性C57BL/6マウス (7週齢) に137Cs線源 (1.24Gy/min) からのγ線を50cGy全身照射し, 経時的に脳および肝臓でのスーパーオキサイドジスムターゼ (SOD) およびカタラーゼ (CAT) の活性変化を24時間後まで検討した。この結果, Cu/Zn-SODは脳および肝臓で照射後早い時期 (12時間以内) に活性上昇がみられ, とりわけ脳で顕著であった。一方Mn-SODは, 脳では顕著な活性変化がみられず, 肝臓では反対に活性低下がみられた。CATについては, いずれの臓器でも, 照射後12時間までに活性上昇がみられた。さらに過酸化脂質 (MDA) 量を測定すると, 両臓器でいずれも顕著な減少がみられた。
AbstractList 小線量放射線の生体内抗酸化系酵素に対する作用を検討する目的で, 雌性C57BL/6マウス (7週齢) に137Cs線源 (1.24Gy/min) からのγ線を50cGy全身照射し, 経時的に脳および肝臓でのスーパーオキサイドジスムターゼ (SOD) およびカタラーゼ (CAT) の活性変化を24時間後まで検討した。この結果, Cu/Zn-SODは脳および肝臓で照射後早い時期 (12時間以内) に活性上昇がみられ, とりわけ脳で顕著であった。一方Mn-SODは, 脳では顕著な活性変化がみられず, 肝臓では反対に活性低下がみられた。CATについては, いずれの臓器でも, 照射後12時間までに活性上昇がみられた。さらに過酸化脂質 (MDA) 量を測定すると, 両臓器でいずれも顕著な減少がみられた。
Author 松木, 修
野村, 崇治
小島, 周二
久保寺, 昭子
山岡, 聖典
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12) Yonezawa, M., Misonoh, J. and Hosokawa Y.: Two types of X-ray-induced radioresistance in mice : Presence of 4 dose ranges with distinct biological effects, Mutat. Res., 358, 237-243 (1996
2) Petkau, A. and Chelack, W.S.: Radioprotective effect of SOD on model phosphplipid membrane, Biochim. Biophys. Acta, 45, 445-456 (1976
8) Shadley, J.D. and Wiencke, J.K.: Induction of the adaptive response by X-ray is dependent on radiation intensity, Int. J. Radiat. Biol., 56, 107-118 (1989
25) Miyachi, Y.: Head-up behavior induced by low dose X-rays and its disappearance by zinc sulfate perfusion in the nasal passage, Behav. Processes, 36, 297-301 (1996
15) Sato, E.F., Yamaoka, K., Yu, H., Morishita, S. and Inoue, M.: Low dose X-ray irradiation induces stress proteins but dose not prevent gastric mucosal lesion, Physiol. Phys. Chem. & Med. NMR, 28, 103-109 (1996
19) Kosower, N.S. and Kosower, E.M.: The glutathione status of cells, Int. Rev. Cytolgy, 54, 109-160 (1976
20) Fuji, J. and Taniguchi, N.: Phorbol ester induces manganese-superoxide dismutase in tumor necrosis factor resistant cells, J. Biol. Chem., 266, 23142-23147 (1991
23) Schonbaum, G.R. and Chance, B.: “Catalase. The Enzyme”, ed. by PD., Boyer, XIII Part C, Chap. 7, pp.363-408, Academic Press (1976
4) Quintiliani, M.: The oxygen effect in radiation interaction on DNA and enzymes, Int. J. Radiat. Biol., 50, 573-594 (1986
14) Ibuki, Y. and Goto, R.: Enhancement of Concanavalin A-induced proliferation of splenolymphocyte by low-dose-irradiated macrophages, J. Radiat. Res., 35, 83-91 (1994
21) Yamaoka, k., Edamatu, R., Ito, T. and Mori, A.: Effect of low dose X-ray irradiation on biomembrane in brain of aged rats, Free Radic. Biol. Med., 6, 529-534 (1994
22) 大山ハルミ, 山田武: 低線量放射線の健康影響-放射線ホルミシス-, Radioisotopes, 46, 360-370 (1997
7) Spector, A., S., Yan, G.Z., Huang, R.R., McDermott, M.J., Gascoyne, P.R.C. and Pigiet, V.: The effect of H2O2 upon thioredoxinenriched lens epithelial cells, J. Biol. Chem., 263, 4984-4990 (1988
5) Asayama, K., Nyfeler, H., English R. L. and Burr, I.M.: Alloxan induced free radical production in isolated cells, Diabetes, 33, 1008-1011 (1984
18) Xia, E., Rao, G., Remmen, H.V., Heydari, A.R. and Richardsan A.: Activities of antioxidant enzymes in various tissues of male fisher 344 rats are altered by food restriction, J. Nutr., 125, 195-201 (1995
10) Sandarson, B.J.S. and Morley, A.A.: Exposure of human lymphocytes to inozing radiation reduces mutagenesis by subsequent inozing radiation, Mutat. Res., 164, 347-351 (1986
17) Kojima S., Matuki, O., Kinosita, I., Valdes Gonzalez, T., Shimura, N. and Kubodera, A.: Does small-dose γ-ray radiation induce endogenous antioxidant potential in vivo Biol. Pharm. Bull., 20, 601-604 (1997
13) Liu, S.Z., Liu, H.W. and Sun, J.B.: Radiation hormesis: its expression in the immune system, Health Phys., 52, 579-583 (1987
16) Ishii, K., Hosoi, Y., Ono, T. and Sakamoto, K.: Enhanced proliferation and IL-1 production of mouse splenocytes by low-dose wholebody X-irradiation, Physiol. Phys. Chem. & Med. NMR, 28, 7-14 (1996
11) Yonezawa, M., Takeda, A. and Misonoh, J.: Acquired radioresistant after low dose Xirradiation in mice, J. Radiat. Res., 31, 256-262 (1991
9) Ibuki, Y. and Goto, R.: Adaptive response to low dose of γ-ray in Chinese hamster cells etermined by cell survival and DNA synthesis, Biol. Pharm. Bull., 17, 1111-1113 (1994
3) Szekely, J.G., Perry, K.A. and Petkau, A.: Stimulated responses to lognormally continuous low radiation doses, Health. Phys., 45, 669-711 (1983
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6) Oberley, L. W. and Oberley, T.D.: Free radicals, cancer and aging, In“Free radical, aging and degenerative diseases”, ed. by Johson Jr., J.E. et al., pp.325-371, Alan R. Liss Inc., New York (1986
26) Miyachi, Y.: Marked decreased radiationinduced emesis by olfactory bulbectomy or pre-exposure using low-dose, Exprientia, 52, 230-233 (1996
References_xml – reference: 7) Spector, A., S., Yan, G.Z., Huang, R.R., McDermott, M.J., Gascoyne, P.R.C. and Pigiet, V.: The effect of H2O2 upon thioredoxinenriched lens epithelial cells, J. Biol. Chem., 263, 4984-4990 (1988)
– reference: 19) Kosower, N.S. and Kosower, E.M.: The glutathione status of cells, Int. Rev. Cytolgy, 54, 109-160 (1976)
– reference: 11) Yonezawa, M., Takeda, A. and Misonoh, J.: Acquired radioresistant after low dose Xirradiation in mice, J. Radiat. Res., 31, 256-262 (1991)
– reference: 4) Quintiliani, M.: The oxygen effect in radiation interaction on DNA and enzymes, Int. J. Radiat. Biol., 50, 573-594 (1986)
– reference: 21) Yamaoka, k., Edamatu, R., Ito, T. and Mori, A.: Effect of low dose X-ray irradiation on biomembrane in brain of aged rats, Free Radic. Biol. Med., 6, 529-534 (1994)
– reference: 16) Ishii, K., Hosoi, Y., Ono, T. and Sakamoto, K.: Enhanced proliferation and IL-1 production of mouse splenocytes by low-dose wholebody X-irradiation, Physiol. Phys. Chem. & Med. NMR, 28, 7-14 (1996)
– reference: 18) Xia, E., Rao, G., Remmen, H.V., Heydari, A.R. and Richardsan A.: Activities of antioxidant enzymes in various tissues of male fisher 344 rats are altered by food restriction, J. Nutr., 125, 195-201 (1995)
– reference: 13) Liu, S.Z., Liu, H.W. and Sun, J.B.: Radiation hormesis: its expression in the immune system, Health Phys., 52, 579-583 (1987)
– reference: 22) 大山ハルミ, 山田武: 低線量放射線の健康影響-放射線ホルミシス-, Radioisotopes, 46, 360-370 (1997)
– reference: 2) Petkau, A. and Chelack, W.S.: Radioprotective effect of SOD on model phosphplipid membrane, Biochim. Biophys. Acta, 45, 445-456 (1976)
– reference: 3) Szekely, J.G., Perry, K.A. and Petkau, A.: Stimulated responses to lognormally continuous low radiation doses, Health. Phys., 45, 669-711 (1983)
– reference: 20) Fuji, J. and Taniguchi, N.: Phorbol ester induces manganese-superoxide dismutase in tumor necrosis factor resistant cells, J. Biol. Chem., 266, 23142-23147 (1991)
– reference: 8) Shadley, J.D. and Wiencke, J.K.: Induction of the adaptive response by X-ray is dependent on radiation intensity, Int. J. Radiat. Biol., 56, 107-118 (1989)
– reference: 14) Ibuki, Y. and Goto, R.: Enhancement of Concanavalin A-induced proliferation of splenolymphocyte by low-dose-irradiated macrophages, J. Radiat. Res., 35, 83-91 (1994)
– reference: 5) Asayama, K., Nyfeler, H., English R. L. and Burr, I.M.: Alloxan induced free radical production in isolated cells, Diabetes, 33, 1008-1011 (1984)
– reference: 26) Miyachi, Y.: Marked decreased radiationinduced emesis by olfactory bulbectomy or pre-exposure using low-dose, Exprientia, 52, 230-233 (1996)
– reference: 25) Miyachi, Y.: Head-up behavior induced by low dose X-rays and its disappearance by zinc sulfate perfusion in the nasal passage, Behav. Processes, 36, 297-301 (1996)
– reference: 24) Miyachi, Y., Koizumi, T. and Yamada, Y.: Immediate arousal response and adaptation to low dose X-rays in mouse and its disappearance by bulbetomy and nitric oxide inhibitor, Neurosci. Lett., 177, 32-34 (1994)
– reference: 15) Sato, E.F., Yamaoka, K., Yu, H., Morishita, S. and Inoue, M.: Low dose X-ray irradiation induces stress proteins but dose not prevent gastric mucosal lesion, Physiol. Phys. Chem. & Med. NMR, 28, 103-109 (1996)
– reference: 1) Mifune, M., Sobue, T., Arimoto, H., Komoto, Y., Kondo, S. and Tanooka, H.: Cancer mortality survey in a Spa area (Misasa, Japan) with a high radon background, Jpn. J. Cancer Res., 83, 1-5 (1992)
– reference: 10) Sandarson, B.J.S. and Morley, A.A.: Exposure of human lymphocytes to inozing radiation reduces mutagenesis by subsequent inozing radiation, Mutat. Res., 164, 347-351 (1986)
– reference: 23) Schonbaum, G.R. and Chance, B.: “Catalase. The Enzyme”, ed. by PD., Boyer, XIII Part C, Chap. 7, pp.363-408, Academic Press (1976)
– reference: 17) Kojima S., Matuki, O., Kinosita, I., Valdes Gonzalez, T., Shimura, N. and Kubodera, A.: Does small-dose γ-ray radiation induce endogenous antioxidant potential in vivo Biol. Pharm. Bull., 20, 601-604 (1997)
– reference: 12) Yonezawa, M., Misonoh, J. and Hosokawa Y.: Two types of X-ray-induced radioresistance in mice : Presence of 4 dose ranges with distinct biological effects, Mutat. Res., 358, 237-243 (1996)
– reference: 9) Ibuki, Y. and Goto, R.: Adaptive response to low dose of γ-ray in Chinese hamster cells etermined by cell survival and DNA synthesis, Biol. Pharm. Bull., 17, 1111-1113 (1994)
– reference: 6) Oberley, L. W. and Oberley, T.D.: Free radicals, cancer and aging, In“Free radical, aging and degenerative diseases”, ed. by Johson Jr., J.E. et al., pp.325-371, Alan R. Liss Inc., New York (1986)
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Snippet 小線量放射線の生体内抗酸化系酵素に対する作用を検討する目的で, 雌性C57BL/6マウス (7週齢) に137Cs線源 (1.24Gy/min) からのγ線を50cGy全身照射し, 経時的に脳および肝臓でのスーパーオキサイドジスムターゼ (SOD) およびカタラーゼ (CAT)...
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Title 小線量γ線のマウス生体内抗酸化系酵素活性に対する作用
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