BLASTOID TRANSFORMATION OF HUMAN LYMPHOCYTES CULTURED WITH PROTEIN-BOUND POLYSACCHARIDE PREPARATION, PS-K, IN VITRO

The protein-bound polysaccharide preparation, PS-K, isolated from a mushroom, Coriolus versicolor, was found to stimulate human lymphocytes and induce them into blastogenesis in vitro. This stimulatory effect seemed to be nonspecific since lymphocytes from cord blood of newborn babies were also stim...

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Published inGANN Japanese Journal of Cancer Research Vol. 67; no. 5; pp. 713 - 716
Main Authors SUGIURA, Sayoko, YAMADA, Kazumasa, OHNO, Ryuzo, YOKOMAKU, Shozo, WAKAYAMA, Kikuko
Format Journal Article
LanguageEnglish
Published Japan The Japanese Cancer Association 01.10.1976
Subjects
Blast formation, in vitro
Cells, Cultured
Fetal Blood
Human lymphocyte
Lymphocyte Activation - drug effects
Proteoglycans - pharmacology
PS-K
Stimulation, Chemical
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ISSN0016-450X
DOI10.20772/cancersci1959.67.5_713

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Summary:The protein-bound polysaccharide preparation, PS-K, isolated from a mushroom, Coriolus versicolor, was found to stimulate human lymphocytes and induce them into blastogenesis in vitro. This stimulatory effect seemed to be nonspecific since lymphocytes from cord blood of newborn babies were also stimulated by PS-K. The highest lymphocyte blastogenesis by PS-K was observed after 5 days in culture.
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ISSN:0016-450X
DOI:10.20772/cancersci1959.67.5_713