Mammary Tumor Suppression by Transforming Growth Factor β1 Transgene Expression
In cell culture, type α transforming growth factor (TGF-α) stimulates epithelial cell growth, whereas TGF-β1 overrides this stimulatory effect and is growth inhibitory. Transgenic mice that overexpress TGF-α under control of the mouse mammary tumor virus (MMTV) promoter/enhancer exhibit mammary duct...
Saved in:
Published in | Proceedings of the National Academy of Sciences - PNAS Vol. 92; no. 10; pp. 4254 - 4258 |
---|---|
Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
National Academy of Sciences of the United States of America
09.05.1995
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | In cell culture, type α transforming growth factor (TGF-α) stimulates epithelial cell growth, whereas TGF-β1 overrides this stimulatory effect and is growth inhibitory. Transgenic mice that overexpress TGF-α under control of the mouse mammary tumor virus (MMTV) promoter/enhancer exhibit mammary ductal hyperplasia and stochastic development of mammary carcinomas, a process that can be accelerated by administration of the chemical carcinogen 7,12-dimethylbenz[a]anthracene. MMTV-TGF-β1 transgenic mice display mammary ductal hypoplasia and do not develop mammary tumors. We report that in crossbreeding experiments involving the production of mice carrying both the MMTV-TGF-β1 and MMTV-TGF-α transgenes, there is marked suppression of mammary tumor formation and that MMTV-TGF-β1 transgenic mice are resistant to 7,12-dimethylbenz[c]anthracene-induced mammary tumor formation. These data demonstrate that overexpression of TGF-β1 in vivo can markedly suppress mammary tumor development. |
---|---|
ISSN: | 0027-8424 1091-6490 |
DOI: | 10.1073/pnas.92.10.4254 |