Neoadjuvant Chemoradiotherapy for a Locally Advanced Carcinoma with Anal Fistula

• Published in: The Japanese Journal of Gastroenterological Surgery Vol. 44; no. 5; pp. 632 - 637
• Main Authors: Obi, Yosiro, Kamimukai, Nobuyuki, Abe, Tetsuo, Nagahori, Yutaka, Endo, Itaru, Homma, Yuki
• Format: Journal Article
• Language: Japanese
• Published: The Japanese Society of Gastroenterological Surgery 2011
• Subjects: abdminosacral resection; Carcinoma associated with anal fistula; neoadjuvant chemoradiotherapy
• ISSN: 0386-9768; 1348-9372
• DOI: 10.5833/jjgs.44.632

We present a case of carcinoma associated with anal fistula, treated by abdomino-sacral resection after neoadjuvant chemoradiotherapy. The patient was a 78-year-old man who had a history of anal fistula for over 40 years. He was admitted to our hospital because of anal bleeding and fever. There was a tumor with mucous discharge on the left side of the anus. There were no distant metastases and no swollen lymph nodes on pelvic CT and MRI. The diameter of the tumor was 7cm. pelvic We performed neoadjuvant chemotherapy preoperatively. The size of the tumor decreased to 2.5cm and tumor marker levels decreased. After chemoradiotherapy, abdminosacral resection was performed. Surgical margins were negative and now the patient is alive with no evidence of recurrence. Neoadjuvant chemoradiotherapy was effective in this case of locally advanced carcinoma with anal fistula.