Complete cytogenetic response obtained with unrelated donor lymphocyte infusion for relapse of chronic myeloid leukemia in blastic crisis after allogeneic bone marrow transplantation

• Published in: Rinshō ketsueki Vol. 42; no. 3; p. 204
• Main Authors: Fujimaki, K, Maruta, A, Yoshida, M, Yamazaki, E, Matsuzaki, M, Fujisawa, S, Kanamori, H, Ishigatsubo, Y
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.03.2001
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Blast Crisis; Bone Marrow Transplantation; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - therapy; Lymphocyte Transfusion; Male; Remission Induction; Tissue Donors
• ISSN: 0485-1439
• DOI: 10.11406/rinketsu.42.204

A 35-year-old man with chronic myeloid leukemia (CML) in blastic crisis (BC) received an allogeneic bone marrow transplant from an unrelated donor in October 1998 after three cycles of chemotherapy. BC relapse developed on day 349 after transplantation. After one cycle of chemotherapy and treatment with interferon, the patient received donor lymphocyte infusion (DLI), and this resulted in a complete cytogenetic response 21 days later. Grade III acute graft-versus-host disease developed on day 25 after DLI, but this was resolved after administration of prednisolone. Disease relapse occurred at extramedullary sites on day 162 after DLI, and the patient died of sepsis after receiving chemotherapy. This case illustrates that unrelated DLI can induce remission successfully in patients with relapse of CML in BC through a graft-versus-leukemia effect.