Treatment for elderly patients with acute non-lymphocytic leukemia

• Published in: Rinshō ketsueki Vol. 36; no. 2; p. 91
• Main Authors: Fujisawa, S, Maruta, A, Ogawa, K, Sakai, R, Taguchi, J, Tomita, N, Kodama, F, Sasaki, S, Fukawa, H, Murata, T
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.02.1995
• Subjects: Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine - administration & dosage; Cytarabine - analogs & derivatives; Daunorubicin - administration & dosage; Female; Humans; Male; Mercaptopurine - administration & dosage; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality; Prednisolone - administration & dosage; Remission Induction; Retrospective Studies; Survival Rate
• ISSN: 0485-1439
• DOI: 10.11406/rinketsu.36.91

A retrospective analysis was performed on forty nine elderly (34 males and 15 females) patients aged 65 years or more (median age 73, range 65-82) with acute non-lymphocytic leukemia (ANLL). Patients were studied to examine factors according to age group (65-69 years, 70-74, 75-79 and 80 or over), respectively. Patients were treated with either low dose Ara-C therapy or BHAC-DMP therapy according of the choice of their attending physicians. Complete remission (CR) was obtained in 20 of 49 patients (43%), and in 6 of 14 patients (43%) aged 65-69, in 8 of 18 (44%) aged 70-74, in 5 of 12 (42%) aged 75-79 years and in 1 of 3 (33%) aged 80 or over, respectively. The median survivals of these groups were 263, 298, 260, 168.5 and 38.5 days, respectively. Multivariate analysis revealed that the achievement of CR was associated with normal karyotype, and serum GOT level < or = 30 mu/ml and GPT < or = 40 mu/ml. Prolonged survival was related to the achievement of CR. The results indicated that liver function before chemotherapy was an important prognostic factor.