Complete remission during administration of rhG-CSF in acute myeloblastic leukemia with pneumonia

A 54-year-old man was admitted with pneumonia and pancytopenia (WBC 400/microliters, RBC 297 x 10(4)/microliters, Hb 10.1g/dl, Plt 5.6 x 10(4)/microliter). Bone marrow aspiration revealed a proliferation of leukemic cells (61.6%) and led the diagnosis of AML (M2). Although no antileukemic agent had...

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Bibliographic Details
Published inRinshō ketsueki Vol. 35; no. 1; p. 59
Main Authors Hayatsu, K, Nagai, K, Abe, A, Murakawa, E, Sekiya, M
Format Journal Article
LanguageJapanese
Published Japan 01.01.1994
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cytarabine - administration & dosage
Cytarabine - analogs & derivatives
Daunorubicin - administration & dosage
Granulocyte Colony-Stimulating Factor - therapeutic use
Humans
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - drug therapy
Male
Mercaptopurine - administration & dosage
Middle Aged
Pancytopenia - etiology
Pancytopenia - therapy
Pneumonia - etiology
Pneumonia - therapy
Prednisolone - administration & dosage
Recombinant Proteins - therapeutic use
Remission Induction
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Summary:A 54-year-old man was admitted with pneumonia and pancytopenia (WBC 400/microliters, RBC 297 x 10(4)/microliters, Hb 10.1g/dl, Plt 5.6 x 10(4)/microliter). Bone marrow aspiration revealed a proliferation of leukemic cells (61.6%) and led the diagnosis of AML (M2). Although no antileukemic agent had been administered previously, the combination therapy of antimicrobials and rhG-CSF for the infection not only improved pneumonia, but also induced a complete remission of AML. The short-term remission was followed by the first relapse of AML, in spite of the continuous administration of rhG-CSF. The abnormal karyotype (47, XY, +8) shown in the chromosomal analysis of the bone marrow cells at admission remained on the first remission. The second complete remission was induced by combination chemotherapy (BHAC-DMP), and the chromosomal analysis at this time showed a normal karyotype. These findings suggested that the first remission of AML in this case was caused mainly by the maturation induction effect of rhG-CSF on the leukemic cells, however, the possibility of the spontaneous remission in this case also remained.
ISSN:0485-1439
DOI:10.11406/rinketsu.35.59