Antifungal Activity of the Novel Adduct, GX-95, of Silver with Nanometer-scale Particles to Peptidic Hydrolysates from Collagen

• Published in: Nihon Ishinkin Gakkai zasshi Vol. 48; no. 2; pp. 97 - 100
• Main Authors: Yaguchi, Takashi, Takizawa, Kayoko, Taguchi, Hideaki, Tanaka, Reiko, Kubota, Tadashi, Kubota, Yoshiaki, Kubota, Masaaki, Fukushima, Kazutaka
• Format: Journal Article
• Language: Japanese
• Published: Japan The Japanese Society for Medical Mycology 2007
• Subjects: antifungal activity; Antifungal Agents - pharmacology; Collagen; Fungi - drug effects; MIC; nanometer-scale particles; Nanoparticles; peptidic hydrolysates from collagen; Protein Hydrolysates; silver; Silver - pharmacology
• ISSN: 0916-4804; 1882-0476
• DOI: 10.3314/jjmm.48.97

Silver has long been known to have an antimicrobial activity against bacteria and other microorganisms, and has been used as eating utensils, as dental fillings and so on. We developed a novel adduct, GX-95, of silver with nanometer-scale particles to peptidic hydrolysates from collagen. Antifungal activity of the adduct against pathogenic yeasts and filamentous fungi was examined in terms of minimal inhibitory concentrations (MICs) . GX-95 was found to possess strong and broad antifungal activities against all fungi examined in the following MICs: 0.25 to 0.31 μg/ml for Candida albicans including resistant strains to fluconazole, itraconazole and flucytosine, 0.05 to 0.2 μg/ml for Cryptococcus neoformans strains, 0.025 to 0.4 μg/ml for Aspergillus fumigatus strains, 0.4 μg/ml for Trichophyton rubrum, and 0.05 μg/ml for Cladophialophora carrionii.