Focal Glomerulosclerosis Histological and clinical study in 13 Cases

Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hyperte...

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Published inNihon Jinzo Gakkai shi Vol. 21; no. 11; pp. 1207 - 1218
Main Authors Saito, Takao, Furuyama, Takashi, Sasaki, Yasuhiko, Kyogoku, Yoshio, Taguma, Yoshio, Arakawa, Masahiro, Yoshinaga, Kaoru, Saito, Hiroshi
Format Journal Article
LanguageJapanese
Published Japan Japanese Society of Nephrology 01.11.1979
Subjects
Adolescent
Adult
Atrophy
Child
Female
Glomerulonephritis - pathology
Glomerulosclerosis, Focal Segmental - pathology
Humans
Hypertension, Renal - pathology
Kidney Glomerulus - ultrastructure
Kidney Tubules - pathology
Male
Nephrotic Syndrome - pathology
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Abstract Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hypertension. All patients were resistant to the therapy, and 4 patients took downhill courses to renal insufficiency. The glomerular sclerosis index (G. S. I.) and the tubular atrophy index (T/S) respectively devised by us were mesured in every biopsy specimen. There was a statistically significant cor-relation between them (r=-0.78, p<0.001).T/S indicated lower values in most of the FGS cases than in the control cases (chronic glomerulonephritis and idiopathic nephrotic syndrome except FGS) whereas the creatinine clearance were nearly equal in the two groups. It is likely that this finding is due to hemodynamic abnormalities frequently occurring FGS patients with nephrotic syndrome or with hypertension.
AbstractList Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hypertension. All patients were resistant to the therapy, and 4 patients took downhill courses to renal insufficiency. The glomerular sclerosis index (G. S. I.) and the tubular atrophy index (T/S) respectively devised by us were mesured in every biopsy specimen. There was a statistically significant cor-relation between them (r=-0.78, p<0.001).T/S indicated lower values in most of the FGS cases than in the control cases (chronic glomerulonephritis and idiopathic nephrotic syndrome except FGS) whereas the creatinine clearance were nearly equal in the two groups. It is likely that this finding is due to hemodynamic abnormalities frequently occurring FGS patients with nephrotic syndrome or with hypertension.
Author Furuyama, Takashi
Arakawa, Masahiro
Saito, Hiroshi
Kyogoku, Yoshio
Yoshinaga, Kaoru
Saito, Takao
Sasaki, Yasuhiko
Taguma, Yoshio
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Snippet Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic...
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SubjectTerms Adolescent
Adult
Atrophy
Child
Female
Glomerulonephritis - pathology
Glomerulosclerosis, Focal Segmental - pathology
Humans
Hypertension, Renal - pathology
Kidney Glomerulus - ultrastructure
Kidney Tubules - pathology
Male
Nephrotic Syndrome - pathology
Subtitle Histological and clinical study in 13 Cases
Title Focal Glomerulosclerosis
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https://www.ncbi.nlm.nih.gov/pubmed/541881
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Volume 21
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