Focal Glomerulosclerosis Histological and clinical study in 13 Cases

• Published in: Nihon Jinzo Gakkai shi Vol. 21; no. 11; pp. 1207 - 1218
• Main Authors: Saito, Takao, Furuyama, Takashi, Sasaki, Yasuhiko, Kyogoku, Yoshio, Taguma, Yoshio, Arakawa, Masahiro, Yoshinaga, Kaoru, Saito, Hiroshi
• Format: Journal Article
• Language: Japanese
• Published: Japan Japanese Society of Nephrology 01.11.1979
• Subjects: Adolescent; Adult; Atrophy; Child; Female; Glomerulonephritis - pathology; Glomerulosclerosis, Focal Segmental - pathology; Humans; Hypertension, Renal - pathology; Kidney Glomerulus - ultrastructure; Kidney Tubules - pathology; Male; Nephrotic Syndrome - pathology
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.21.11_1207

Out of 1500 cases examined by biopsy in our clinic, 13 cases were diagnosed as focal glomerulo-sclerosis (FGS) because of more than three (>10%) sclerotic glomeruli with hyaline deposits in their biopsy specimens. Clinically, 11 patients had nephrotic syndrome and the other 2 patients had hypertension. All patients were resistant to the therapy, and 4 patients took downhill courses to renal insufficiency. The glomerular sclerosis index (G. S. I.) and the tubular atrophy index (T/S) respectively devised by us were mesured in every biopsy specimen. There was a statistically significant cor-relation between them (r=-0.78, p<0.001).T/S indicated lower values in most of the FGS cases than in the control cases (chronic glomerulonephritis and idiopathic nephrotic syndrome except FGS) whereas the creatinine clearance were nearly equal in the two groups. It is likely that this finding is due to hemodynamic abnormalities frequently occurring FGS patients with nephrotic syndrome or with hypertension.