2. NK細胞によるウィルス感染細胞認識機構

NK細胞はウィルス感染細胞や腫瘍細胞に細胞障害性を持つ細胞として, 生体防御において重要な機能を担っていると考えられている. NK細胞の標的細胞認識機構は長年不明であったが, 最近, ようやくある種のNK細胞レセプターが特異的にウイルス産物を認識することが明らかになってきた. さらに, NK細胞レセプターは, 活性化と抑制化からなるペア型レセプターを形成するが, それらによるウィルス感染細胞の認識パターンがウィルスに対する感染抵抗性を決定していることが判明した. そこで, 本稿ではNK細胞によるウィルス感染細胞の認識機構を中心に, 最近の知見をふまえ紹介する....

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Published inウイルス Vol. 54; no. 2; pp. 153 - 160
Main Authors 荒瀬, 尚, 白鳥, 行大
Format Journal Article
LanguageJapanese
Published 日本ウイルス学会 2004
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ISSN0042-6857
1884-3433
DOI10.2222/jsv.54.153

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Abstract NK細胞はウィルス感染細胞や腫瘍細胞に細胞障害性を持つ細胞として, 生体防御において重要な機能を担っていると考えられている. NK細胞の標的細胞認識機構は長年不明であったが, 最近, ようやくある種のNK細胞レセプターが特異的にウイルス産物を認識することが明らかになってきた. さらに, NK細胞レセプターは, 活性化と抑制化からなるペア型レセプターを形成するが, それらによるウィルス感染細胞の認識パターンがウィルスに対する感染抵抗性を決定していることが判明した. そこで, 本稿ではNK細胞によるウィルス感染細胞の認識機構を中心に, 最近の知見をふまえ紹介する.
AbstractList NK細胞はウィルス感染細胞や腫瘍細胞に細胞障害性を持つ細胞として, 生体防御において重要な機能を担っていると考えられている. NK細胞の標的細胞認識機構は長年不明であったが, 最近, ようやくある種のNK細胞レセプターが特異的にウイルス産物を認識することが明らかになってきた. さらに, NK細胞レセプターは, 活性化と抑制化からなるペア型レセプターを形成するが, それらによるウィルス感染細胞の認識パターンがウィルスに対する感染抵抗性を決定していることが判明した. そこで, 本稿ではNK細胞によるウィルス感染細胞の認識機構を中心に, 最近の知見をふまえ紹介する.
Author 荒瀬, 尚
白鳥, 行大
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References 12) Kanazawa N, Tashiro K, Inaba K, Miyachi Y. : Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain. J Biol Chem. 278 : 32645-32652, 2003.
22) Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM, Blom B, Homola ME, Streit WJ, Brown MH, Barclay AN, Sedgwick JD. : Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science. 290 : 1768-1771, 2000.
4) Wu J, Song Y, Bakker ABH, Bauer S, Groh V, Spies T, Lanier LL, Phillips JH. : An activating receptor complex on natural killer and T cells formed by NKG2D and DAP10. Science. 285 : 730-732, 1999.
10) Cosman D, Fanger N, Borges L, Kibin M, Chin W, Peterson L, Hsu M-L. : A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 7 : 273-282, 1997.
7) Iizuka K, Naidenko OV, Plougastel BF, Fremont DH, Yokoyama WM. : Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Nat Immunol, 10, 2003.
14) Shiratori I, Ogasawara K, Saito T, Lanier LL, Arase H. : Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med. 199 : 525-533, 2004.
8) Oldenborg PA, Zheleznyak A, Fang YF, Lagenaur CF, Gresham HD, Lindberg FP. : Role of CD47 as a marker of self on red blood cells. Science. 288 : 2051-2054, 2000.
16) Reyburn HT, Mandelbolm O, Vales-Gomez M, Davis DM, Pazmany L, Strominger JL. : The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells. Nature. 386 : 514-517, 1997.
1) Karre K, Ljunggren HG, Piontek G, Kiessling R. : Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy. Nature. 319 : 675-678, 1986.
13) Gorczynski R, Chen Z, Kai Y, Lee L, Wong S, Marsden PA. : CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. J Immunol. 172 : 7744-7749, 2004.
15) Beck S, Barrell BG. : Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature. 331 : 269-272, 1988.
18) Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL. : Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors. Science. 296 : 1323-1326, 2002.
11) Yotsumoto K, Okoshi Y, Shibuya K, Yamazaki S, Tahara-Hanaoka S, Honda S, Osawa M, Kuroiwa A, Matsuda Y, Tenen DG, Iwama A, Nakauchi H, Shibuya A. : Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med. 198 : 223-233, 2003.
17) Cretney E, Degli-Esposti MA, Densley EH, Farrell HE, Davis-Poynter NJ, Smyth MJ. : m144, a Murine Cytomegalovirus (MCMV) -encoded Major Histocompatibility Complex Class I Homologue, Confers Tumor Resistance to Natural Killer Cell-mediated Rejection. J Exp Med. 190 : 435-444, 1999.
5) Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colonna M. : NKG2D recruits two distinct adapters to trigger NK cell activation, costimulation. Nat Immunol. 3 : 1150-1155, 2002.
21) Arase H, Lanier LL. : Specific recognition of virus-infected cells by paired NK receptors. Rev Med Virol. 14 : 83-93, 2004.
20) Smith HR, Heusel JW, Mehta IK, Kim S, Dorner BG, Naidenko OV, Iizuka K, Furukawa H, Beckman DL, Pingel JT, Scalzo AA, Fremont DH, Yokoyama WM. : Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc Natl Acad Sci U S A. 99 : 8826-8831, 2002.
9) Blery M, Kubagawa H, Chen C-C, Vely F, Cooper MD, Vivier E. : The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. USA. 95 : 2446-2451, 1998.
2) Biron CA, Byron KS, Sullivan JL. : Severe herpesvirus infections in an adolescent without natural killer cells. N. Eng. J. Med. 320 : 1731-1735, 1989.
3) Yokoyama WM, Plougastel BF. : Immune functions encoded by the natural killer gene complex. Nat Rev Immunol. 3 : 304-316, 2003.
6) Giorda R, Rudert WA, Vavassori C, Chambers WH, Hiserodt JC, Trucco M. : NKR-P1, a signal transduction molecule on natural killer cells. Science. 249 : 1298-1300, 1990.
19) Brown MG, Dokun AO, Heusel JW, Smith HR, Beckman DL, Blattenberger EA, Dubbelde CE, Stone LR, Scalzo AA, Yokoyama WM. : Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 292 : 934-937., 2001.
References_xml – reference: 22) Hoek RM, Ruuls SR, Murphy CA, Wright GJ, Goddard R, Zurawski SM, Blom B, Homola ME, Streit WJ, Brown MH, Barclay AN, Sedgwick JD. : Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science. 290 : 1768-1771, 2000.
– reference: 15) Beck S, Barrell BG. : Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature. 331 : 269-272, 1988.
– reference: 14) Shiratori I, Ogasawara K, Saito T, Lanier LL, Arase H. : Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med. 199 : 525-533, 2004.
– reference: 7) Iizuka K, Naidenko OV, Plougastel BF, Fremont DH, Yokoyama WM. : Genetically linked C-type lectin-related ligands for the NKRP1 family of natural killer cell receptors. Nat Immunol, 10, 2003.
– reference: 19) Brown MG, Dokun AO, Heusel JW, Smith HR, Beckman DL, Blattenberger EA, Dubbelde CE, Stone LR, Scalzo AA, Yokoyama WM. : Vital involvement of a natural killer cell activation receptor in resistance to viral infection. Science. 292 : 934-937., 2001.
– reference: 4) Wu J, Song Y, Bakker ABH, Bauer S, Groh V, Spies T, Lanier LL, Phillips JH. : An activating receptor complex on natural killer and T cells formed by NKG2D and DAP10. Science. 285 : 730-732, 1999.
– reference: 18) Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL. : Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors. Science. 296 : 1323-1326, 2002.
– reference: 5) Gilfillan S, Ho EL, Cella M, Yokoyama WM, Colonna M. : NKG2D recruits two distinct adapters to trigger NK cell activation, costimulation. Nat Immunol. 3 : 1150-1155, 2002.
– reference: 8) Oldenborg PA, Zheleznyak A, Fang YF, Lagenaur CF, Gresham HD, Lindberg FP. : Role of CD47 as a marker of self on red blood cells. Science. 288 : 2051-2054, 2000.
– reference: 11) Yotsumoto K, Okoshi Y, Shibuya K, Yamazaki S, Tahara-Hanaoka S, Honda S, Osawa M, Kuroiwa A, Matsuda Y, Tenen DG, Iwama A, Nakauchi H, Shibuya A. : Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med. 198 : 223-233, 2003.
– reference: 1) Karre K, Ljunggren HG, Piontek G, Kiessling R. : Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defense strategy. Nature. 319 : 675-678, 1986.
– reference: 2) Biron CA, Byron KS, Sullivan JL. : Severe herpesvirus infections in an adolescent without natural killer cells. N. Eng. J. Med. 320 : 1731-1735, 1989.
– reference: 20) Smith HR, Heusel JW, Mehta IK, Kim S, Dorner BG, Naidenko OV, Iizuka K, Furukawa H, Beckman DL, Pingel JT, Scalzo AA, Fremont DH, Yokoyama WM. : Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc Natl Acad Sci U S A. 99 : 8826-8831, 2002.
– reference: 3) Yokoyama WM, Plougastel BF. : Immune functions encoded by the natural killer gene complex. Nat Rev Immunol. 3 : 304-316, 2003.
– reference: 6) Giorda R, Rudert WA, Vavassori C, Chambers WH, Hiserodt JC, Trucco M. : NKR-P1, a signal transduction molecule on natural killer cells. Science. 249 : 1298-1300, 1990.
– reference: 12) Kanazawa N, Tashiro K, Inaba K, Miyachi Y. : Dendritic cell immunoactivating receptor, a novel C-type lectin immunoreceptor, acts as an activating receptor through association with Fc receptor gamma chain. J Biol Chem. 278 : 32645-32652, 2003.
– reference: 17) Cretney E, Degli-Esposti MA, Densley EH, Farrell HE, Davis-Poynter NJ, Smyth MJ. : m144, a Murine Cytomegalovirus (MCMV) -encoded Major Histocompatibility Complex Class I Homologue, Confers Tumor Resistance to Natural Killer Cell-mediated Rejection. J Exp Med. 190 : 435-444, 1999.
– reference: 9) Blery M, Kubagawa H, Chen C-C, Vely F, Cooper MD, Vivier E. : The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. USA. 95 : 2446-2451, 1998.
– reference: 13) Gorczynski R, Chen Z, Kai Y, Lee L, Wong S, Marsden PA. : CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. J Immunol. 172 : 7744-7749, 2004.
– reference: 21) Arase H, Lanier LL. : Specific recognition of virus-infected cells by paired NK receptors. Rev Med Virol. 14 : 83-93, 2004.
– reference: 10) Cosman D, Fanger N, Borges L, Kibin M, Chin W, Peterson L, Hsu M-L. : A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 7 : 273-282, 1997.
– reference: 16) Reyburn HT, Mandelbolm O, Vales-Gomez M, Davis DM, Pazmany L, Strominger JL. : The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells. Nature. 386 : 514-517, 1997.
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Snippet NK細胞はウィルス感染細胞や腫瘍細胞に細胞障害性を持つ細胞として, 生体防御において重要な機能を担っていると考えられている. NK細胞の標的細胞認識機構は長年不明であったが, 最近, ようやくある種のNK細胞レセプターが特異的にウイルス産物を認識することが明らかになってきた. さらに, NK細胞レセプターは,...
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Title 2. NK細胞によるウィルス感染細胞認識機構
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