Renal osteodystrophy and growth in children undergoing CAPD

• Published in: Nihon Jinzo Gakkai shi Vol. 33; no. 8; pp. 779 - 790
• Main Authors: ITO, TAMIE, HORIIKE, SHIGEHARU, IITAKA, KIKUO
• Format: Journal Article
• Language: Japanese
• Published: Japan Japanese Society of Nephrology 01.08.1991
• Subjects: Adolescent; Age Factors; Alkaline Phosphatase - blood; Bone Development; Calcium - blood; CAPD; Child; Child, Preschool; Chronic Kidney Disease-Mineral and Bone Disorder - etiology; Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology; Chronic Kidney Disease-Mineral and Bone Disorder - prevention & control; Female; growth; Humans; Hyperparathyroidism - etiology; Hyperparathyroidism - physiopathology; Infant; Kidney Failure, Chronic - blood; Kidney Failure, Chronic - complications; Male; Parathyroid Hormone - blood; Peritoneal Dialysis, Continuous Ambulatory - adverse effects; Phosphorus - blood; renal osteodystrophy; rickets; Rickets - etiology; Rickets - physiopathology; secondary hyperparathyroidism; Vitamin D - therapeutic use
• ISSN: 0385-2385; 1884-0728
• DOI: 10.14842/jpnjnephrol1959.33.779

Renal osteodystrophy (ROD) and growth were assessed in 20 children undergoing CAPD. Serum calcium and inorganic phosphorus levels were maintained with normal limits in these patients. Elevated alkaline phosphatase and c-PTH levels and abnormal radiological bone changes of ROD were observed in patients with severe ROD, but they were not correlated each other in patients with mild ROD. Fifteen patients showed the radiological bone changes of ROD with deterioration and improvement in some patients, and administration of vitamin D seems to be necessary to prevent ROD during CAPD treatment. The growth of older children was poor during CAPD, but catch up growth was observed in young children under the age of 7 years. The growth was affected by rickets in young children, but the presence of mild secondary hyperparathyroidisms seemed to have little influence on growth in older children.