Evaluation of renal function in chronic renal disease with special reference to creatinine

Creatinine clearaece (Ccr) has been used to evaluate glomerular filtration rate (GFR) in patients with various kinds and grade of renal disease. It is quite useful in terms of simplicity, accuracy and convenience in clinical medicine. However, for the purpose of clinical research, it is not adequate...

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Published inNihon Jinzo Gakkai shi Vol. 32; no. 7; pp. 745 - 750
Main Author SUGINO, NOBUHIRO
Format Journal Article
LanguageJapanese
Published Japan Japanese Society of Nephrology 01.07.1990
Subjects
Creatinine - metabolism
Glomerular Filtration Rate
Humans
Kidney - physiopathology
Kidney Failure, Chronic - physiopathology
Kidney Function Tests
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Summary:Creatinine clearaece (Ccr) has been used to evaluate glomerular filtration rate (GFR) in patients with various kinds and grade of renal disease. It is quite useful in terms of simplicity, accuracy and convenience in clinical medicine. However, for the purpose of clinical research, it is not adequate to assess GFR, since a significant quantity of creatinine is secreted in the renal tubule. The secretion rate is rather increased in the endstage chronic renal disease, misleading the true GFR. It also induces an error to calculate the progression rate of a patient with chronic renal failure or to evaluate the effect of the drugs or diet therapy. Therefore, some other indices should be, in future, investigated in order to establish the quantitative evaluation of GFR in patients with chronic renal failure in stead of Ccr or serum creatinine.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0385-2385
1884-0728
DOI:10.14842/jpnjnephrol1959.32.745