Double primary lung carcinoma consisting of large cell neuroendocrine carcinoma and squamous cell carcinoma: report of a case

• Published in: Annals of thoracic and cardiovascular surgery Vol. 11; no. 6; pp. 397 - 400
• Main Authors: Yamada, Yoshito, Iyoda, Akira, Suzuki, Makoto, Mizobuchi, Teruaki, Baba, Masayuki, Hiroshima, Kenzo, Ohwada, Hidemi, Fujisawa, Takehiko
• Format: Journal Article
• Language: English
• Published: Japan 01.12.2005
• Subjects: Aged; Carcinoma, Large Cell - pathology; Carcinoma, Large Cell - surgery; Carcinoma, Neuroendocrine - pathology; Carcinoma, Neuroendocrine - surgery; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - surgery; Humans; Lung Neoplasms - pathology; Lung Neoplasms - surgery; Lymphatic Metastasis; Male; Neoplasms, Multiple Primary - pathology; Neoplasms, Multiple Primary - surgery; Pneumonectomy
• ISSN: 1341-1098

We report a rare case of double primary lung carcinoma including large cell neuroendocrine carcinoma (LCNEC). A 67-year-old man underwent an annual medical checkup in 2000, pulmonary carcinoma was strongly suspected by sputum cytology and radiological images. Preoperative diagnosis was double primary lung carcinoma with a squamous cell carcinoma in the right lower lobe and non-small cell carcinoma in the right upper lobe. The histological carcinoma type in the right upper lobe could not be determined preoperatively. The patient underwent a right lower lobectomy and wedge resection of the right upper lobe. Histologically, the tumor in the right upper lobe was LCNEC and the tumor in the right lower lobe was a moderately differentiated squamous cell carcinoma. The patient had right supraclavicular lymph node metastases of LCNEC and died of multiple pulmonary metastases 10 months after the operation.